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Multi-level variations of lateral habenula in depression: A comprehensive review of current evidence
Despite extensive research in recent decades, knowledge of the pathophysiology of depression in neural circuits remains limited. Recently, the lateral habenula (LHb) has been extensively reported to undergo a series of adaptive changes at multiple levels during the depression state. As a crucial rel...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649931/ https://www.ncbi.nlm.nih.gov/pubmed/36386995 http://dx.doi.org/10.3389/fpsyt.2022.1043846 |
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author | Zhang, Guang-Ming Wu, Hong-Yun Cui, Wen-Qiang Peng, Wei |
author_facet | Zhang, Guang-Ming Wu, Hong-Yun Cui, Wen-Qiang Peng, Wei |
author_sort | Zhang, Guang-Ming |
collection | PubMed |
description | Despite extensive research in recent decades, knowledge of the pathophysiology of depression in neural circuits remains limited. Recently, the lateral habenula (LHb) has been extensively reported to undergo a series of adaptive changes at multiple levels during the depression state. As a crucial relay in brain networks associated with emotion regulation, LHb receives excitatory or inhibitory projections from upstream brain regions related to stress and cognition and interacts with brain regions involved in emotion regulation. A series of pathological alterations induced by aberrant inputs cause abnormal function of the LHb, resulting in dysregulation of mood and motivation, which present with depressive-like phenotypes in rodents. Herein, we systematically combed advances from rodents, summarized changes in the LHb and related neural circuits in depression, and attempted to analyze the intrinsic logical relationship among these pathological alterations. We expect that this summary will greatly enhance our understanding of the pathological processes of depression. This is advantageous for fostering the understanding and screening of potential antidepressant targets against LHb. |
format | Online Article Text |
id | pubmed-9649931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96499312022-11-15 Multi-level variations of lateral habenula in depression: A comprehensive review of current evidence Zhang, Guang-Ming Wu, Hong-Yun Cui, Wen-Qiang Peng, Wei Front Psychiatry Psychiatry Despite extensive research in recent decades, knowledge of the pathophysiology of depression in neural circuits remains limited. Recently, the lateral habenula (LHb) has been extensively reported to undergo a series of adaptive changes at multiple levels during the depression state. As a crucial relay in brain networks associated with emotion regulation, LHb receives excitatory or inhibitory projections from upstream brain regions related to stress and cognition and interacts with brain regions involved in emotion regulation. A series of pathological alterations induced by aberrant inputs cause abnormal function of the LHb, resulting in dysregulation of mood and motivation, which present with depressive-like phenotypes in rodents. Herein, we systematically combed advances from rodents, summarized changes in the LHb and related neural circuits in depression, and attempted to analyze the intrinsic logical relationship among these pathological alterations. We expect that this summary will greatly enhance our understanding of the pathological processes of depression. This is advantageous for fostering the understanding and screening of potential antidepressant targets against LHb. Frontiers Media S.A. 2022-10-28 /pmc/articles/PMC9649931/ /pubmed/36386995 http://dx.doi.org/10.3389/fpsyt.2022.1043846 Text en Copyright © 2022 Zhang, Wu, Cui and Peng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Zhang, Guang-Ming Wu, Hong-Yun Cui, Wen-Qiang Peng, Wei Multi-level variations of lateral habenula in depression: A comprehensive review of current evidence |
title | Multi-level variations of lateral habenula in depression: A comprehensive review of current evidence |
title_full | Multi-level variations of lateral habenula in depression: A comprehensive review of current evidence |
title_fullStr | Multi-level variations of lateral habenula in depression: A comprehensive review of current evidence |
title_full_unstemmed | Multi-level variations of lateral habenula in depression: A comprehensive review of current evidence |
title_short | Multi-level variations of lateral habenula in depression: A comprehensive review of current evidence |
title_sort | multi-level variations of lateral habenula in depression: a comprehensive review of current evidence |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649931/ https://www.ncbi.nlm.nih.gov/pubmed/36386995 http://dx.doi.org/10.3389/fpsyt.2022.1043846 |
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