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The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities

This review discusses the long-term effects of early-life environment on epileptogenesis, epilepsy, and neuropsychiatric comorbidities with an emphasis on the absence epilepsy. The WAG/Rij rat strain is a well-validated genetic model of absence epilepsy with mild depression-like (dysthymia) comorbid...

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Autores principales: Sarkisova, Karine, van Luijtelaar, Gilles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649966/
https://www.ncbi.nlm.nih.gov/pubmed/36386598
http://dx.doi.org/10.1016/j.ibneur.2022.10.012
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author Sarkisova, Karine
van Luijtelaar, Gilles
author_facet Sarkisova, Karine
van Luijtelaar, Gilles
author_sort Sarkisova, Karine
collection PubMed
description This review discusses the long-term effects of early-life environment on epileptogenesis, epilepsy, and neuropsychiatric comorbidities with an emphasis on the absence epilepsy. The WAG/Rij rat strain is a well-validated genetic model of absence epilepsy with mild depression-like (dysthymia) comorbidity. Although pathologic phenotype in WAG/Rij rats is genetically determined, convincing evidence presented in this review suggests that the absence epilepsy and depression-like comorbidity in WAG/Rij rats may be governed by early-life events, such as prenatal drug exposure, early-life stress, neonatal maternal separation, neonatal handling, maternal care, environmental enrichment, neonatal sensory impairments, neonatal tactile stimulation, and maternal diet. The data, as presented here, indicate that some early environmental events can promote and accelerate the development of absence seizures and their neuropsychiatric comorbidities, while others may exert anti-epileptogenic and disease-modifying effects. The early environment can lead to phenotypic alterations in offspring due to epigenetic modifications of gene expression, which may have maladaptive consequences or represent a therapeutic value. Targeting DNA methylation with a maternal methyl-enriched diet during the perinatal period appears to be a new preventive epigenetic anti-absence therapy. A number of caveats related to the maternal methyl-enriched diet and prospects for future research are discussed.
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spelling pubmed-96499662022-11-15 The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities Sarkisova, Karine van Luijtelaar, Gilles IBRO Neurosci Rep Article This review discusses the long-term effects of early-life environment on epileptogenesis, epilepsy, and neuropsychiatric comorbidities with an emphasis on the absence epilepsy. The WAG/Rij rat strain is a well-validated genetic model of absence epilepsy with mild depression-like (dysthymia) comorbidity. Although pathologic phenotype in WAG/Rij rats is genetically determined, convincing evidence presented in this review suggests that the absence epilepsy and depression-like comorbidity in WAG/Rij rats may be governed by early-life events, such as prenatal drug exposure, early-life stress, neonatal maternal separation, neonatal handling, maternal care, environmental enrichment, neonatal sensory impairments, neonatal tactile stimulation, and maternal diet. The data, as presented here, indicate that some early environmental events can promote and accelerate the development of absence seizures and their neuropsychiatric comorbidities, while others may exert anti-epileptogenic and disease-modifying effects. The early environment can lead to phenotypic alterations in offspring due to epigenetic modifications of gene expression, which may have maladaptive consequences or represent a therapeutic value. Targeting DNA methylation with a maternal methyl-enriched diet during the perinatal period appears to be a new preventive epigenetic anti-absence therapy. A number of caveats related to the maternal methyl-enriched diet and prospects for future research are discussed. Elsevier 2022-11-09 /pmc/articles/PMC9649966/ /pubmed/36386598 http://dx.doi.org/10.1016/j.ibneur.2022.10.012 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Sarkisova, Karine
van Luijtelaar, Gilles
The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities
title The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities
title_full The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities
title_fullStr The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities
title_full_unstemmed The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities
title_short The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities
title_sort impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649966/
https://www.ncbi.nlm.nih.gov/pubmed/36386598
http://dx.doi.org/10.1016/j.ibneur.2022.10.012
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