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The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities
This review discusses the long-term effects of early-life environment on epileptogenesis, epilepsy, and neuropsychiatric comorbidities with an emphasis on the absence epilepsy. The WAG/Rij rat strain is a well-validated genetic model of absence epilepsy with mild depression-like (dysthymia) comorbid...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649966/ https://www.ncbi.nlm.nih.gov/pubmed/36386598 http://dx.doi.org/10.1016/j.ibneur.2022.10.012 |
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author | Sarkisova, Karine van Luijtelaar, Gilles |
author_facet | Sarkisova, Karine van Luijtelaar, Gilles |
author_sort | Sarkisova, Karine |
collection | PubMed |
description | This review discusses the long-term effects of early-life environment on epileptogenesis, epilepsy, and neuropsychiatric comorbidities with an emphasis on the absence epilepsy. The WAG/Rij rat strain is a well-validated genetic model of absence epilepsy with mild depression-like (dysthymia) comorbidity. Although pathologic phenotype in WAG/Rij rats is genetically determined, convincing evidence presented in this review suggests that the absence epilepsy and depression-like comorbidity in WAG/Rij rats may be governed by early-life events, such as prenatal drug exposure, early-life stress, neonatal maternal separation, neonatal handling, maternal care, environmental enrichment, neonatal sensory impairments, neonatal tactile stimulation, and maternal diet. The data, as presented here, indicate that some early environmental events can promote and accelerate the development of absence seizures and their neuropsychiatric comorbidities, while others may exert anti-epileptogenic and disease-modifying effects. The early environment can lead to phenotypic alterations in offspring due to epigenetic modifications of gene expression, which may have maladaptive consequences or represent a therapeutic value. Targeting DNA methylation with a maternal methyl-enriched diet during the perinatal period appears to be a new preventive epigenetic anti-absence therapy. A number of caveats related to the maternal methyl-enriched diet and prospects for future research are discussed. |
format | Online Article Text |
id | pubmed-9649966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-96499662022-11-15 The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities Sarkisova, Karine van Luijtelaar, Gilles IBRO Neurosci Rep Article This review discusses the long-term effects of early-life environment on epileptogenesis, epilepsy, and neuropsychiatric comorbidities with an emphasis on the absence epilepsy. The WAG/Rij rat strain is a well-validated genetic model of absence epilepsy with mild depression-like (dysthymia) comorbidity. Although pathologic phenotype in WAG/Rij rats is genetically determined, convincing evidence presented in this review suggests that the absence epilepsy and depression-like comorbidity in WAG/Rij rats may be governed by early-life events, such as prenatal drug exposure, early-life stress, neonatal maternal separation, neonatal handling, maternal care, environmental enrichment, neonatal sensory impairments, neonatal tactile stimulation, and maternal diet. The data, as presented here, indicate that some early environmental events can promote and accelerate the development of absence seizures and their neuropsychiatric comorbidities, while others may exert anti-epileptogenic and disease-modifying effects. The early environment can lead to phenotypic alterations in offspring due to epigenetic modifications of gene expression, which may have maladaptive consequences or represent a therapeutic value. Targeting DNA methylation with a maternal methyl-enriched diet during the perinatal period appears to be a new preventive epigenetic anti-absence therapy. A number of caveats related to the maternal methyl-enriched diet and prospects for future research are discussed. Elsevier 2022-11-09 /pmc/articles/PMC9649966/ /pubmed/36386598 http://dx.doi.org/10.1016/j.ibneur.2022.10.012 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Sarkisova, Karine van Luijtelaar, Gilles The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities |
title | The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities |
title_full | The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities |
title_fullStr | The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities |
title_full_unstemmed | The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities |
title_short | The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities |
title_sort | impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649966/ https://www.ncbi.nlm.nih.gov/pubmed/36386598 http://dx.doi.org/10.1016/j.ibneur.2022.10.012 |
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