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Radiological patterns and pulmonary function values of lung involvement in primary Sjögren’s syndrome: A pilot analysis
BACKGROUND: Lung involvement in primary Sjögren’s syndrome (pSS) may vary from 9 to 90%. Interstitial lung disease and tracheobronchial alterations are the most typical findings. The evidence of primarily emphysematous changes at computed tomography of the chest of pSS patients has occasionally been...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649970/ https://www.ncbi.nlm.nih.gov/pubmed/36388884 http://dx.doi.org/10.3389/fmed.2022.998028 |
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author | Mormile, Ilaria Mormile, Mauro Rossi, Francesca Wanda Williams, Michela Valente, Tullio Candia, Claudio Granata, Francescopaolo Rega, Roberto Orlandi, Martina Matucci-Cerinic, Marco Molino, Antonio de Paulis, Amato |
author_facet | Mormile, Ilaria Mormile, Mauro Rossi, Francesca Wanda Williams, Michela Valente, Tullio Candia, Claudio Granata, Francescopaolo Rega, Roberto Orlandi, Martina Matucci-Cerinic, Marco Molino, Antonio de Paulis, Amato |
author_sort | Mormile, Ilaria |
collection | PubMed |
description | BACKGROUND: Lung involvement in primary Sjögren’s syndrome (pSS) may vary from 9 to 90%. Interstitial lung disease and tracheobronchial alterations are the most typical findings. The evidence of primarily emphysematous changes at computed tomography of the chest of pSS patients has occasionally been described but poorly characterized. This study aims to assess pulmonary involvement and the impact on respiratory function in a cohort of pSS patients. MATERIALS AND METHODS: A total of 22 consecutive patients diagnosed with pSS underwent pulmonary function tests to investigate the presence of ventilatory impairment and evaluate the exchanges of alveolar gases. All patients underwent a chest high-resolution computed tomography (HRTC). RESULTS: Dynamic volumes were within the normal range in 21 patients (95.4%). A reduction in the diffusing capacity of the lung for carbon monoxide (DLCO) was observed in 18 patients (81.8%). Ten (45.5%) patients showed a mild degree deficit, while 8 patients (36%) showed a moderate degree deficit. Analysis of DLCO revealed a significant difference between pSS patients and controls [t(30.98) = −10.77; p < 0.001], showing a higher DLCO value for the healthy controls (mean ± SE; 101.27 ± 6.08) compared to pSS patients (mean ± SE; 65.95 ± 12.78). Emphysema was found in 21 (94.5%) patients and was the most widespread pulmonary injury. Tracheal thickness was reduced in 15 (67%) patients. Micronodules were observed in 10 (45%) patients in all the pulmonary fields. Bronchial wall thickening and bronchiectasis were observed in 8 (36%) patients, mainly in the lower lobes. Ground glass was found in 5 (22.5%) patients in lower and higher lobes. Cysts were observed in two patients (9%). CONCLUSION: The reduction of the DLCO could be related to early emphysematous alterations in the absence of spirometric alterations and relevant respiratory symptoms. In conclusion, emphysema might be seen as an early pulmonary involvement mark in patients suffering from pSS. |
format | Online Article Text |
id | pubmed-9649970 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96499702022-11-15 Radiological patterns and pulmonary function values of lung involvement in primary Sjögren’s syndrome: A pilot analysis Mormile, Ilaria Mormile, Mauro Rossi, Francesca Wanda Williams, Michela Valente, Tullio Candia, Claudio Granata, Francescopaolo Rega, Roberto Orlandi, Martina Matucci-Cerinic, Marco Molino, Antonio de Paulis, Amato Front Med (Lausanne) Medicine BACKGROUND: Lung involvement in primary Sjögren’s syndrome (pSS) may vary from 9 to 90%. Interstitial lung disease and tracheobronchial alterations are the most typical findings. The evidence of primarily emphysematous changes at computed tomography of the chest of pSS patients has occasionally been described but poorly characterized. This study aims to assess pulmonary involvement and the impact on respiratory function in a cohort of pSS patients. MATERIALS AND METHODS: A total of 22 consecutive patients diagnosed with pSS underwent pulmonary function tests to investigate the presence of ventilatory impairment and evaluate the exchanges of alveolar gases. All patients underwent a chest high-resolution computed tomography (HRTC). RESULTS: Dynamic volumes were within the normal range in 21 patients (95.4%). A reduction in the diffusing capacity of the lung for carbon monoxide (DLCO) was observed in 18 patients (81.8%). Ten (45.5%) patients showed a mild degree deficit, while 8 patients (36%) showed a moderate degree deficit. Analysis of DLCO revealed a significant difference between pSS patients and controls [t(30.98) = −10.77; p < 0.001], showing a higher DLCO value for the healthy controls (mean ± SE; 101.27 ± 6.08) compared to pSS patients (mean ± SE; 65.95 ± 12.78). Emphysema was found in 21 (94.5%) patients and was the most widespread pulmonary injury. Tracheal thickness was reduced in 15 (67%) patients. Micronodules were observed in 10 (45%) patients in all the pulmonary fields. Bronchial wall thickening and bronchiectasis were observed in 8 (36%) patients, mainly in the lower lobes. Ground glass was found in 5 (22.5%) patients in lower and higher lobes. Cysts were observed in two patients (9%). CONCLUSION: The reduction of the DLCO could be related to early emphysematous alterations in the absence of spirometric alterations and relevant respiratory symptoms. In conclusion, emphysema might be seen as an early pulmonary involvement mark in patients suffering from pSS. Frontiers Media S.A. 2022-10-28 /pmc/articles/PMC9649970/ /pubmed/36388884 http://dx.doi.org/10.3389/fmed.2022.998028 Text en Copyright © 2022 Mormile, Mormile, Rossi, Williams, Valente, Candia, Granata, Rega, Orlandi, Matucci-Cerinic, Molino and de Paulis. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Mormile, Ilaria Mormile, Mauro Rossi, Francesca Wanda Williams, Michela Valente, Tullio Candia, Claudio Granata, Francescopaolo Rega, Roberto Orlandi, Martina Matucci-Cerinic, Marco Molino, Antonio de Paulis, Amato Radiological patterns and pulmonary function values of lung involvement in primary Sjögren’s syndrome: A pilot analysis |
title | Radiological patterns and pulmonary function values of lung involvement in primary Sjögren’s syndrome: A pilot analysis |
title_full | Radiological patterns and pulmonary function values of lung involvement in primary Sjögren’s syndrome: A pilot analysis |
title_fullStr | Radiological patterns and pulmonary function values of lung involvement in primary Sjögren’s syndrome: A pilot analysis |
title_full_unstemmed | Radiological patterns and pulmonary function values of lung involvement in primary Sjögren’s syndrome: A pilot analysis |
title_short | Radiological patterns and pulmonary function values of lung involvement in primary Sjögren’s syndrome: A pilot analysis |
title_sort | radiological patterns and pulmonary function values of lung involvement in primary sjögren’s syndrome: a pilot analysis |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649970/ https://www.ncbi.nlm.nih.gov/pubmed/36388884 http://dx.doi.org/10.3389/fmed.2022.998028 |
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