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Synthesis, characterization, molecular docking and biological evaluation of Schiff Base derivatives of cefpodoxime

Synthesis of new Cefpodoxime derivatives via Schiff Bases mechanism and the efficiency of their antimicrobial and antiviral activities were addressed. They were analyzed for structural validation by using spectroscopic techniques using FTIR, (1)HNMR, and (13)CNMR. Molecular docking against IBV Virus...

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Autores principales: Mahmood, Waqas, Ahmad, Irshad, Khan, Mohsin Abbas, Ali Shah, Syed Adnan, Ashraf, Muhammad, Shahzad, Mirza Imran, Pervaiz, Irfan, Sajid-ur-Rehman, Muhammad, Khurshid, Umair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649975/
https://www.ncbi.nlm.nih.gov/pubmed/36387450
http://dx.doi.org/10.1016/j.heliyon.2022.e11332
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author Mahmood, Waqas
Ahmad, Irshad
Khan, Mohsin Abbas
Ali Shah, Syed Adnan
Ashraf, Muhammad
Shahzad, Mirza Imran
Pervaiz, Irfan
Sajid-ur-Rehman, Muhammad
Khurshid, Umair
author_facet Mahmood, Waqas
Ahmad, Irshad
Khan, Mohsin Abbas
Ali Shah, Syed Adnan
Ashraf, Muhammad
Shahzad, Mirza Imran
Pervaiz, Irfan
Sajid-ur-Rehman, Muhammad
Khurshid, Umair
author_sort Mahmood, Waqas
collection PubMed
description Synthesis of new Cefpodoxime derivatives via Schiff Bases mechanism and the efficiency of their antimicrobial and antiviral activities were addressed. They were analyzed for structural validation by using spectroscopic techniques using FTIR, (1)HNMR, and (13)CNMR. Molecular docking against IBV Virus papain-like protease (PLPro) was done with Auto dock tools against compounds having excellent IC(50) values against IBV (Corona Class) virus. All derivatives showed strong zone of inhibition ranges from (55 ± 2.0 to 70 ± 0.8 mm) against E. coli. Compounds 1,2,4 and 6 derivatives showed remarkable activity against Stenotrophomonas maltophilia and Serratia marcescens. But For most the newly synthesized derivatives C(1) (64 ± 1.60), C(3) (32 ± 0.80), and C(8) (64 ± 1.60) showed potential IC(50) values against two variants of Corona class viruses i.e. Avian Influenza (H9) and Avian corona (IBV) viruses. The current study revealed that newly synthesized Schiff Bases possessed strong anti-viral potential. Further studies may make a breakthrough in medical sciences to tackle latest challenges such as Corona Virus Diseases.
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spelling pubmed-96499752022-11-15 Synthesis, characterization, molecular docking and biological evaluation of Schiff Base derivatives of cefpodoxime Mahmood, Waqas Ahmad, Irshad Khan, Mohsin Abbas Ali Shah, Syed Adnan Ashraf, Muhammad Shahzad, Mirza Imran Pervaiz, Irfan Sajid-ur-Rehman, Muhammad Khurshid, Umair Heliyon Research Article Synthesis of new Cefpodoxime derivatives via Schiff Bases mechanism and the efficiency of their antimicrobial and antiviral activities were addressed. They were analyzed for structural validation by using spectroscopic techniques using FTIR, (1)HNMR, and (13)CNMR. Molecular docking against IBV Virus papain-like protease (PLPro) was done with Auto dock tools against compounds having excellent IC(50) values against IBV (Corona Class) virus. All derivatives showed strong zone of inhibition ranges from (55 ± 2.0 to 70 ± 0.8 mm) against E. coli. Compounds 1,2,4 and 6 derivatives showed remarkable activity against Stenotrophomonas maltophilia and Serratia marcescens. But For most the newly synthesized derivatives C(1) (64 ± 1.60), C(3) (32 ± 0.80), and C(8) (64 ± 1.60) showed potential IC(50) values against two variants of Corona class viruses i.e. Avian Influenza (H9) and Avian corona (IBV) viruses. The current study revealed that newly synthesized Schiff Bases possessed strong anti-viral potential. Further studies may make a breakthrough in medical sciences to tackle latest challenges such as Corona Virus Diseases. Elsevier 2022-11-02 /pmc/articles/PMC9649975/ /pubmed/36387450 http://dx.doi.org/10.1016/j.heliyon.2022.e11332 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Mahmood, Waqas
Ahmad, Irshad
Khan, Mohsin Abbas
Ali Shah, Syed Adnan
Ashraf, Muhammad
Shahzad, Mirza Imran
Pervaiz, Irfan
Sajid-ur-Rehman, Muhammad
Khurshid, Umair
Synthesis, characterization, molecular docking and biological evaluation of Schiff Base derivatives of cefpodoxime
title Synthesis, characterization, molecular docking and biological evaluation of Schiff Base derivatives of cefpodoxime
title_full Synthesis, characterization, molecular docking and biological evaluation of Schiff Base derivatives of cefpodoxime
title_fullStr Synthesis, characterization, molecular docking and biological evaluation of Schiff Base derivatives of cefpodoxime
title_full_unstemmed Synthesis, characterization, molecular docking and biological evaluation of Schiff Base derivatives of cefpodoxime
title_short Synthesis, characterization, molecular docking and biological evaluation of Schiff Base derivatives of cefpodoxime
title_sort synthesis, characterization, molecular docking and biological evaluation of schiff base derivatives of cefpodoxime
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649975/
https://www.ncbi.nlm.nih.gov/pubmed/36387450
http://dx.doi.org/10.1016/j.heliyon.2022.e11332
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