Cargando…

Rhythmic auditory cueing in atypical parkinsonism: A pilot study

Rhythmic auditory cueing (RAC) can improve gait parameters in neurological disorders such as Parkinson's disease and stroke. However, there is a lack of research on the effects of RAC in patients with atypical parkinsonian disorders (APD). Using a smartphone metronome application, we aimed to i...

Descripción completa

Detalles Bibliográficos
Autores principales: Pantelyat, Alexander, Dayanim, Gabriel, Kang, Kyurim, Turk, Bela, Pagkatipunan, Ruben, Huenergard, Sera-Kim, Mears, Albert, Bang, Jee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650086/
https://www.ncbi.nlm.nih.gov/pubmed/36388209
http://dx.doi.org/10.3389/fneur.2022.1018206
_version_ 1784827935027363840
author Pantelyat, Alexander
Dayanim, Gabriel
Kang, Kyurim
Turk, Bela
Pagkatipunan, Ruben
Huenergard, Sera-Kim
Mears, Albert
Bang, Jee
author_facet Pantelyat, Alexander
Dayanim, Gabriel
Kang, Kyurim
Turk, Bela
Pagkatipunan, Ruben
Huenergard, Sera-Kim
Mears, Albert
Bang, Jee
author_sort Pantelyat, Alexander
collection PubMed
description Rhythmic auditory cueing (RAC) can improve gait parameters in neurological disorders such as Parkinson's disease and stroke. However, there is a lack of research on the effects of RAC in patients with atypical parkinsonian disorders (APD). Using a smartphone metronome application, we aimed to investigate the immediate effects of RAC in patients with clinically diagnosed APD, namely Progressive Supranuclear Palsy (PSP-Richardson Syndrome and other variants, PSP-nonRS), Corticobasal Syndrome (CBS), Multiple System Atrophy (MSA), and Dementia with Lewy Bodies (DLB). A total of 46 APD participants (25 PSP, 9 CBS, 8 MSA and 4 DLB; age: mean = 70.17, standard deviation = 7.15) walked at their preferred pace for 2 min without any rhythmic auditory cueing (RAC). Participants then walked the same path for another 2 min with RAC set at a tempo 10% faster than the baseline cadence of each participant. After a 10–15-min break, participants walked the same path for another 2 min without RAC to observe for carryover effects. Gait parameters [cadence (steps/minute), gait velocity (meters/minute), and stride length (centimeters)] were collected at baseline, during RAC, and post-RAC. There was a significant improvement in cadence in all participants from baseline to during RAC and post-RAC (corrected p-values = 0.009 for both). Gait velocity also improved from baseline to during RAC and post-RAC in all participants, although this improvement was not significant after correcting for multiple comparisons. The changes in cadence and gait velocity were most pronounced in PSP. In addition, our exploratory analysis showed that the cadence in the suspected TAU group (PSP+CBS) showed a significant improvement from baseline to during RAC and post-RAC (corr. p-value = 0.004 for both). This pilot study using short-term RAC in APD patients demonstrated improvements in cadence and velocity. There is an urgent need for effective gait rehabilitation modalities for patients with APD, and rhythmic cueing can be a practical and useful intervention to improve their gait pattern.
format Online
Article
Text
id pubmed-9650086
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-96500862022-11-15 Rhythmic auditory cueing in atypical parkinsonism: A pilot study Pantelyat, Alexander Dayanim, Gabriel Kang, Kyurim Turk, Bela Pagkatipunan, Ruben Huenergard, Sera-Kim Mears, Albert Bang, Jee Front Neurol Neurology Rhythmic auditory cueing (RAC) can improve gait parameters in neurological disorders such as Parkinson's disease and stroke. However, there is a lack of research on the effects of RAC in patients with atypical parkinsonian disorders (APD). Using a smartphone metronome application, we aimed to investigate the immediate effects of RAC in patients with clinically diagnosed APD, namely Progressive Supranuclear Palsy (PSP-Richardson Syndrome and other variants, PSP-nonRS), Corticobasal Syndrome (CBS), Multiple System Atrophy (MSA), and Dementia with Lewy Bodies (DLB). A total of 46 APD participants (25 PSP, 9 CBS, 8 MSA and 4 DLB; age: mean = 70.17, standard deviation = 7.15) walked at their preferred pace for 2 min without any rhythmic auditory cueing (RAC). Participants then walked the same path for another 2 min with RAC set at a tempo 10% faster than the baseline cadence of each participant. After a 10–15-min break, participants walked the same path for another 2 min without RAC to observe for carryover effects. Gait parameters [cadence (steps/minute), gait velocity (meters/minute), and stride length (centimeters)] were collected at baseline, during RAC, and post-RAC. There was a significant improvement in cadence in all participants from baseline to during RAC and post-RAC (corrected p-values = 0.009 for both). Gait velocity also improved from baseline to during RAC and post-RAC in all participants, although this improvement was not significant after correcting for multiple comparisons. The changes in cadence and gait velocity were most pronounced in PSP. In addition, our exploratory analysis showed that the cadence in the suspected TAU group (PSP+CBS) showed a significant improvement from baseline to during RAC and post-RAC (corr. p-value = 0.004 for both). This pilot study using short-term RAC in APD patients demonstrated improvements in cadence and velocity. There is an urgent need for effective gait rehabilitation modalities for patients with APD, and rhythmic cueing can be a practical and useful intervention to improve their gait pattern. Frontiers Media S.A. 2022-10-28 /pmc/articles/PMC9650086/ /pubmed/36388209 http://dx.doi.org/10.3389/fneur.2022.1018206 Text en Copyright © 2022 Pantelyat, Dayanim, Kang, Turk, Pagkatipunan, Huenergard, Mears and Bang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Pantelyat, Alexander
Dayanim, Gabriel
Kang, Kyurim
Turk, Bela
Pagkatipunan, Ruben
Huenergard, Sera-Kim
Mears, Albert
Bang, Jee
Rhythmic auditory cueing in atypical parkinsonism: A pilot study
title Rhythmic auditory cueing in atypical parkinsonism: A pilot study
title_full Rhythmic auditory cueing in atypical parkinsonism: A pilot study
title_fullStr Rhythmic auditory cueing in atypical parkinsonism: A pilot study
title_full_unstemmed Rhythmic auditory cueing in atypical parkinsonism: A pilot study
title_short Rhythmic auditory cueing in atypical parkinsonism: A pilot study
title_sort rhythmic auditory cueing in atypical parkinsonism: a pilot study
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650086/
https://www.ncbi.nlm.nih.gov/pubmed/36388209
http://dx.doi.org/10.3389/fneur.2022.1018206
work_keys_str_mv AT pantelyatalexander rhythmicauditorycueinginatypicalparkinsonismapilotstudy
AT dayanimgabriel rhythmicauditorycueinginatypicalparkinsonismapilotstudy
AT kangkyurim rhythmicauditorycueinginatypicalparkinsonismapilotstudy
AT turkbela rhythmicauditorycueinginatypicalparkinsonismapilotstudy
AT pagkatipunanruben rhythmicauditorycueinginatypicalparkinsonismapilotstudy
AT huenergardserakim rhythmicauditorycueinginatypicalparkinsonismapilotstudy
AT mearsalbert rhythmicauditorycueinginatypicalparkinsonismapilotstudy
AT bangjee rhythmicauditorycueinginatypicalparkinsonismapilotstudy