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Case Report: Congenital disseminated tuberculosis neonate born to tuberculosis- COVID-19 mother

We report a case of a 26-day-old male neonate with high suggestive of congenital disseminated tuberculosis (TB) [tuberculous meningitis (TBM), pulmonary TB, and ocular TB] at term, low birth weight born cesarean section from a confirmed COVID-19 and pulmonary TB mother who hospitalized in the isolat...

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Autores principales: Risan, Nelly Amalia, Febrianda, Rilda Dwi, Nataprawira, Heda Melinda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650132/
https://www.ncbi.nlm.nih.gov/pubmed/36389374
http://dx.doi.org/10.3389/fped.2022.941570
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author Risan, Nelly Amalia
Febrianda, Rilda Dwi
Nataprawira, Heda Melinda
author_facet Risan, Nelly Amalia
Febrianda, Rilda Dwi
Nataprawira, Heda Melinda
author_sort Risan, Nelly Amalia
collection PubMed
description We report a case of a 26-day-old male neonate with high suggestive of congenital disseminated tuberculosis (TB) [tuberculous meningitis (TBM), pulmonary TB, and ocular TB] at term, low birth weight born cesarean section from a confirmed COVID-19 and pulmonary TB mother who hospitalized in the isolation room and never seen her son for three weeks. The baby had a fever for two weeks after birth and a history of seizures. A nasopharyngeal swab for RT-PCR SARS-CoV-2 yielded a negative result. He was initially diagnosed as having a sepsis-like syndrome and then hospitalized. Chest x-ray revealed bilateral infiltrate, cerebrospinal fluid analysis (CSF) showed clear, cell count was 9 with dominant mononuclear cell, and gastric lavages did not yield acid-fast bacilli. X-pert MTB/RIF from gastric lavage specimen detected Mycobacterium tuberculosis rifampicin sensitive. Anti-tuberculosis drugs for TBM were started. Abdominal sonography identified multiple hypoechoic nodules in the liver and spleen. Neuroimaging studies did not identify hydrocephalus, meningeal enhancement, infarct, or tuberculoma. A Video-EEG examination showed electrical seizure after initiation of phenobarbital. Video-EEG evaluation showed no epileptiform discharge. Upon follow-up, he showed slightly delayed motor development, pan-uveitis, retinal detachment, and cataracts. We assumed that ocular TB resulted from a paradoxical reaction following TB treatment. Retinal detachment was improved and lens replacement was done.
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spelling pubmed-96501322022-11-15 Case Report: Congenital disseminated tuberculosis neonate born to tuberculosis- COVID-19 mother Risan, Nelly Amalia Febrianda, Rilda Dwi Nataprawira, Heda Melinda Front Pediatr Pediatrics We report a case of a 26-day-old male neonate with high suggestive of congenital disseminated tuberculosis (TB) [tuberculous meningitis (TBM), pulmonary TB, and ocular TB] at term, low birth weight born cesarean section from a confirmed COVID-19 and pulmonary TB mother who hospitalized in the isolation room and never seen her son for three weeks. The baby had a fever for two weeks after birth and a history of seizures. A nasopharyngeal swab for RT-PCR SARS-CoV-2 yielded a negative result. He was initially diagnosed as having a sepsis-like syndrome and then hospitalized. Chest x-ray revealed bilateral infiltrate, cerebrospinal fluid analysis (CSF) showed clear, cell count was 9 with dominant mononuclear cell, and gastric lavages did not yield acid-fast bacilli. X-pert MTB/RIF from gastric lavage specimen detected Mycobacterium tuberculosis rifampicin sensitive. Anti-tuberculosis drugs for TBM were started. Abdominal sonography identified multiple hypoechoic nodules in the liver and spleen. Neuroimaging studies did not identify hydrocephalus, meningeal enhancement, infarct, or tuberculoma. A Video-EEG examination showed electrical seizure after initiation of phenobarbital. Video-EEG evaluation showed no epileptiform discharge. Upon follow-up, he showed slightly delayed motor development, pan-uveitis, retinal detachment, and cataracts. We assumed that ocular TB resulted from a paradoxical reaction following TB treatment. Retinal detachment was improved and lens replacement was done. Frontiers Media S.A. 2022-10-28 /pmc/articles/PMC9650132/ /pubmed/36389374 http://dx.doi.org/10.3389/fped.2022.941570 Text en © 2022 Risan, Febrianda and Nataprawira. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Risan, Nelly Amalia
Febrianda, Rilda Dwi
Nataprawira, Heda Melinda
Case Report: Congenital disseminated tuberculosis neonate born to tuberculosis- COVID-19 mother
title Case Report: Congenital disseminated tuberculosis neonate born to tuberculosis- COVID-19 mother
title_full Case Report: Congenital disseminated tuberculosis neonate born to tuberculosis- COVID-19 mother
title_fullStr Case Report: Congenital disseminated tuberculosis neonate born to tuberculosis- COVID-19 mother
title_full_unstemmed Case Report: Congenital disseminated tuberculosis neonate born to tuberculosis- COVID-19 mother
title_short Case Report: Congenital disseminated tuberculosis neonate born to tuberculosis- COVID-19 mother
title_sort case report: congenital disseminated tuberculosis neonate born to tuberculosis- covid-19 mother
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650132/
https://www.ncbi.nlm.nih.gov/pubmed/36389374
http://dx.doi.org/10.3389/fped.2022.941570
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