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Cross-sectional area of psoas muscle as a predictive marker of anastomotic failure in male rectal cancer patients: Japanese single institutional retrospective observational study

PURPOSE: Preoperative sarcopenia worsens postoperative outcomes in various cancer types including colorectal cancer. However, we often experienced postoperative anastomotic leakage in muscular male patients such as Judo players, especially in rectal cancer surgery with lower anastomosis. It is contr...

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Autores principales: Mizuuchi, Yusuke, Tanabe, Yoshitaka, Sada, Masafumi, Tamura, Koji, Nagayoshi, Kinuko, Nagai, Shuntaro, Watanabe, Yusuke, Tamiya, Sadafumi, Nakata, Kohei, Ohuchida, Kenoki, Nakano, Toru, Nakamura, Masafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Coloproctology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650344/
https://www.ncbi.nlm.nih.gov/pubmed/35410111
http://dx.doi.org/10.3393/ac.2022.00122.0017
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author Mizuuchi, Yusuke
Tanabe, Yoshitaka
Sada, Masafumi
Tamura, Koji
Nagayoshi, Kinuko
Nagai, Shuntaro
Watanabe, Yusuke
Tamiya, Sadafumi
Nakata, Kohei
Ohuchida, Kenoki
Nakano, Toru
Nakamura, Masafumi
author_facet Mizuuchi, Yusuke
Tanabe, Yoshitaka
Sada, Masafumi
Tamura, Koji
Nagayoshi, Kinuko
Nagai, Shuntaro
Watanabe, Yusuke
Tamiya, Sadafumi
Nakata, Kohei
Ohuchida, Kenoki
Nakano, Toru
Nakamura, Masafumi
author_sort Mizuuchi, Yusuke
collection PubMed
description PURPOSE: Preoperative sarcopenia worsens postoperative outcomes in various cancer types including colorectal cancer. However, we often experienced postoperative anastomotic leakage in muscular male patients such as Judo players, especially in rectal cancer surgery with lower anastomosis. It is controversial whether the whole skeletal muscle mass impacts the potential for anastomotic failure in male rectal cancer patients. Thus, the purpose of this study was to clarify whether skeletal muscle mass impacts anastomotic leakage in rectal cancer in men. METHODS: We reviewed the medical charts of male patients suffering from rectal cancer who underwent colo-procto anastomosis below the peritoneal reflection without a protective diverting stoma. We measured the psoas muscle area and calculated the psoas muscle index. RESULTS: One hundred ninety-seven male rectal cancer patients were enrolled in this study. The psoas muscle index was significantly higher in patients with anastomotic leakage (P<0.001). Receiver operating characteristic curve determined the optimal cut-off value of the psoas muscle index for predicting anastomotic leakage as 812.67 cm(2)/m(2) (sensitivity of 60% and specificity of 74.3%). Multivariate analysis revealed that high psoas muscle index (risk ratio [RR], 3.933; P<0.001; 95% confidence interval [CI], 1.917–8.070) and super low anastomosis (RR, 2.792; P=0.015; 95% CI, 1.221–6.384) were independent predictive factors of anastomotic leakage. CONCLUSION: This study showed that male rectal cancer patients with a large psoas muscle mass who underwent lower anastomosis had a higher rate of postoperative anastomotic leakage.
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spelling pubmed-96503442022-11-22 Cross-sectional area of psoas muscle as a predictive marker of anastomotic failure in male rectal cancer patients: Japanese single institutional retrospective observational study Mizuuchi, Yusuke Tanabe, Yoshitaka Sada, Masafumi Tamura, Koji Nagayoshi, Kinuko Nagai, Shuntaro Watanabe, Yusuke Tamiya, Sadafumi Nakata, Kohei Ohuchida, Kenoki Nakano, Toru Nakamura, Masafumi Ann Coloproctol Original Article PURPOSE: Preoperative sarcopenia worsens postoperative outcomes in various cancer types including colorectal cancer. However, we often experienced postoperative anastomotic leakage in muscular male patients such as Judo players, especially in rectal cancer surgery with lower anastomosis. It is controversial whether the whole skeletal muscle mass impacts the potential for anastomotic failure in male rectal cancer patients. Thus, the purpose of this study was to clarify whether skeletal muscle mass impacts anastomotic leakage in rectal cancer in men. METHODS: We reviewed the medical charts of male patients suffering from rectal cancer who underwent colo-procto anastomosis below the peritoneal reflection without a protective diverting stoma. We measured the psoas muscle area and calculated the psoas muscle index. RESULTS: One hundred ninety-seven male rectal cancer patients were enrolled in this study. The psoas muscle index was significantly higher in patients with anastomotic leakage (P<0.001). Receiver operating characteristic curve determined the optimal cut-off value of the psoas muscle index for predicting anastomotic leakage as 812.67 cm(2)/m(2) (sensitivity of 60% and specificity of 74.3%). Multivariate analysis revealed that high psoas muscle index (risk ratio [RR], 3.933; P<0.001; 95% confidence interval [CI], 1.917–8.070) and super low anastomosis (RR, 2.792; P=0.015; 95% CI, 1.221–6.384) were independent predictive factors of anastomotic leakage. CONCLUSION: This study showed that male rectal cancer patients with a large psoas muscle mass who underwent lower anastomosis had a higher rate of postoperative anastomotic leakage. Korean Society of Coloproctology 2022-10 2022-04-12 /pmc/articles/PMC9650344/ /pubmed/35410111 http://dx.doi.org/10.3393/ac.2022.00122.0017 Text en Copyright © 2022 The Korean Society of Coloproctology https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Mizuuchi, Yusuke
Tanabe, Yoshitaka
Sada, Masafumi
Tamura, Koji
Nagayoshi, Kinuko
Nagai, Shuntaro
Watanabe, Yusuke
Tamiya, Sadafumi
Nakata, Kohei
Ohuchida, Kenoki
Nakano, Toru
Nakamura, Masafumi
Cross-sectional area of psoas muscle as a predictive marker of anastomotic failure in male rectal cancer patients: Japanese single institutional retrospective observational study
title Cross-sectional area of psoas muscle as a predictive marker of anastomotic failure in male rectal cancer patients: Japanese single institutional retrospective observational study
title_full Cross-sectional area of psoas muscle as a predictive marker of anastomotic failure in male rectal cancer patients: Japanese single institutional retrospective observational study
title_fullStr Cross-sectional area of psoas muscle as a predictive marker of anastomotic failure in male rectal cancer patients: Japanese single institutional retrospective observational study
title_full_unstemmed Cross-sectional area of psoas muscle as a predictive marker of anastomotic failure in male rectal cancer patients: Japanese single institutional retrospective observational study
title_short Cross-sectional area of psoas muscle as a predictive marker of anastomotic failure in male rectal cancer patients: Japanese single institutional retrospective observational study
title_sort cross-sectional area of psoas muscle as a predictive marker of anastomotic failure in male rectal cancer patients: japanese single institutional retrospective observational study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650344/
https://www.ncbi.nlm.nih.gov/pubmed/35410111
http://dx.doi.org/10.3393/ac.2022.00122.0017
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