Local extreme map guided multi-modal brain image fusion

Multi-modal brain image fusion targets on integrating the salient and complementary features of different modalities of brain images into a comprehensive image. The well-fused brain image will make it convenient for doctors to precisely examine the brain diseases and can be input to intelligent systems to automatically detect the possible diseases. In order to achieve the above purpose, we have proposed a local extreme map guided multi-modal brain image fusion method. First, each source image is iteratively smoothed by the local extreme map guided image filter. Specifically, in each iteration, the guidance image is alternatively set to the local minimum map of the input image and local maximum map of previously filtered image. With the iteratively smoothed images, multiple scales of bright and dark feature maps of each source image can be gradually extracted from the difference image of every two continuously smoothed images. Then, the multiple scales of bright feature maps and base images (i.e., final-scale smoothed images) of the source images are fused by the elementwise-maximum fusion rule, respectively, and the multiple scales of dark feature maps of the source images are fused by the elementwise-minimum fusion rule. Finally, the fused bright feature map, dark feature map, and base image are integrated together to generate a single informative brain image. Extensive experiments verify that the proposed method outperforms eight state-of-the-art (SOTA) image fusion methods from both qualitative and quantitative aspects and demonstrates great application potential to clinical scenarios.