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Inferring miRNA sponge modules across major neuropsychiatric disorders

The role of non-coding RNAs in neuropsychiatric disorders (NPDs) is an emerging field of study. The long non-coding RNAs (lncRNAs) are shown to sponge the microRNAs (miRNAs) from interacting with their target mRNAs. Investigating the sponge activity of lncRNAs in NPDs will provide further insights i...

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Autores principales: Balasubramanian, Rami, Vinod, P. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650411/
https://www.ncbi.nlm.nih.gov/pubmed/36385761
http://dx.doi.org/10.3389/fnmol.2022.1009662
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author Balasubramanian, Rami
Vinod, P. K.
author_facet Balasubramanian, Rami
Vinod, P. K.
author_sort Balasubramanian, Rami
collection PubMed
description The role of non-coding RNAs in neuropsychiatric disorders (NPDs) is an emerging field of study. The long non-coding RNAs (lncRNAs) are shown to sponge the microRNAs (miRNAs) from interacting with their target mRNAs. Investigating the sponge activity of lncRNAs in NPDs will provide further insights into biological mechanisms and help identify disease biomarkers. In this study, a large-scale inference of the lncRNA-related miRNA sponge network of pan-neuropsychiatric disorders, including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD), was carried out using brain transcriptomic (RNA-Seq) data. The candidate miRNA sponge modules were identified based on the co-expression pattern of non-coding RNAs, sharing of miRNA binding sites, and sensitivity canonical correlation. miRNA sponge modules are associated with chemical synaptic transmission, nervous system development, metabolism, immune system response, ribosomes, and pathways in cancer. The identified modules showed similar and distinct gene expression patterns depending on the neuropsychiatric condition. The preservation of miRNA sponge modules was shown in the independent brain and blood-transcriptomic datasets of NPDs. We also identified miRNA sponging lncRNAs that may be potential diagnostic biomarkers for NPDs. Our study provides a comprehensive resource on miRNA sponging in NPDs.
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spelling pubmed-96504112022-11-15 Inferring miRNA sponge modules across major neuropsychiatric disorders Balasubramanian, Rami Vinod, P. K. Front Mol Neurosci Molecular Neuroscience The role of non-coding RNAs in neuropsychiatric disorders (NPDs) is an emerging field of study. The long non-coding RNAs (lncRNAs) are shown to sponge the microRNAs (miRNAs) from interacting with their target mRNAs. Investigating the sponge activity of lncRNAs in NPDs will provide further insights into biological mechanisms and help identify disease biomarkers. In this study, a large-scale inference of the lncRNA-related miRNA sponge network of pan-neuropsychiatric disorders, including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD), was carried out using brain transcriptomic (RNA-Seq) data. The candidate miRNA sponge modules were identified based on the co-expression pattern of non-coding RNAs, sharing of miRNA binding sites, and sensitivity canonical correlation. miRNA sponge modules are associated with chemical synaptic transmission, nervous system development, metabolism, immune system response, ribosomes, and pathways in cancer. The identified modules showed similar and distinct gene expression patterns depending on the neuropsychiatric condition. The preservation of miRNA sponge modules was shown in the independent brain and blood-transcriptomic datasets of NPDs. We also identified miRNA sponging lncRNAs that may be potential diagnostic biomarkers for NPDs. Our study provides a comprehensive resource on miRNA sponging in NPDs. Frontiers Media S.A. 2022-10-28 /pmc/articles/PMC9650411/ /pubmed/36385761 http://dx.doi.org/10.3389/fnmol.2022.1009662 Text en Copyright © 2022 Balasubramanian and Vinod. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Neuroscience
Balasubramanian, Rami
Vinod, P. K.
Inferring miRNA sponge modules across major neuropsychiatric disorders
title Inferring miRNA sponge modules across major neuropsychiatric disorders
title_full Inferring miRNA sponge modules across major neuropsychiatric disorders
title_fullStr Inferring miRNA sponge modules across major neuropsychiatric disorders
title_full_unstemmed Inferring miRNA sponge modules across major neuropsychiatric disorders
title_short Inferring miRNA sponge modules across major neuropsychiatric disorders
title_sort inferring mirna sponge modules across major neuropsychiatric disorders
topic Molecular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650411/
https://www.ncbi.nlm.nih.gov/pubmed/36385761
http://dx.doi.org/10.3389/fnmol.2022.1009662
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