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Pathogenicity evaluation of GVI-1 lineage infectious bronchitis virus and its long-term effects on reproductive system development in SPF hens
Infectious bronchitis virus (IBV) has gained increasing attention in the poultry industry due to its ability to cause tissue injuries not only in the respiratory system and kidney but also in the reproductive system of layers. Recently, the GVI-1 lineage IBVs have spread widely in China, whereas the...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650418/ https://www.ncbi.nlm.nih.gov/pubmed/36386629 http://dx.doi.org/10.3389/fmicb.2022.1049287 |
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author | Bo, Zongyi Chen, Shuqin Zhang, Chengcheng Guo, Menjiao Cao, Yongzhong Zhang, Xiaorong Wu, Yantao |
author_facet | Bo, Zongyi Chen, Shuqin Zhang, Chengcheng Guo, Menjiao Cao, Yongzhong Zhang, Xiaorong Wu, Yantao |
author_sort | Bo, Zongyi |
collection | PubMed |
description | Infectious bronchitis virus (IBV) has gained increasing attention in the poultry industry due to its ability to cause tissue injuries not only in the respiratory system and kidney but also in the reproductive system of layers. Recently, the GVI-1 lineage IBVs have spread widely in China, whereas their pathogenicity in egg-laying chickens has rarely been studied, especially its long-term influence in egg production upon the early infection in chicks. In this study, 10-day-old SPF chicks were infected with the GVI-1 lineage JX181 strain and monitored over a 170-day period after infection. The pathogenicity evaluation of the JX181 strain included clinical observations, immunohistochemical assay, viral load, viral shedding, gross autopsy, and laying rate. The results showed that JX181 has a high pathogenicity, causing severe system lesions, and the decrease in egg production. In summary, this study describes the long-term damages caused by the early infection with the IBV GVI-1 lineage on the reproductive system of hens, providing a comprehensive understanding of the pathogenicity of the IBV GVI-1 lineage and emphasizing the importance of its early prevention. |
format | Online Article Text |
id | pubmed-9650418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96504182022-11-15 Pathogenicity evaluation of GVI-1 lineage infectious bronchitis virus and its long-term effects on reproductive system development in SPF hens Bo, Zongyi Chen, Shuqin Zhang, Chengcheng Guo, Menjiao Cao, Yongzhong Zhang, Xiaorong Wu, Yantao Front Microbiol Microbiology Infectious bronchitis virus (IBV) has gained increasing attention in the poultry industry due to its ability to cause tissue injuries not only in the respiratory system and kidney but also in the reproductive system of layers. Recently, the GVI-1 lineage IBVs have spread widely in China, whereas their pathogenicity in egg-laying chickens has rarely been studied, especially its long-term influence in egg production upon the early infection in chicks. In this study, 10-day-old SPF chicks were infected with the GVI-1 lineage JX181 strain and monitored over a 170-day period after infection. The pathogenicity evaluation of the JX181 strain included clinical observations, immunohistochemical assay, viral load, viral shedding, gross autopsy, and laying rate. The results showed that JX181 has a high pathogenicity, causing severe system lesions, and the decrease in egg production. In summary, this study describes the long-term damages caused by the early infection with the IBV GVI-1 lineage on the reproductive system of hens, providing a comprehensive understanding of the pathogenicity of the IBV GVI-1 lineage and emphasizing the importance of its early prevention. Frontiers Media S.A. 2022-10-28 /pmc/articles/PMC9650418/ /pubmed/36386629 http://dx.doi.org/10.3389/fmicb.2022.1049287 Text en Copyright © 2022 Bo, Chen, Zhang, Guo, Cao, Zhang and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Bo, Zongyi Chen, Shuqin Zhang, Chengcheng Guo, Menjiao Cao, Yongzhong Zhang, Xiaorong Wu, Yantao Pathogenicity evaluation of GVI-1 lineage infectious bronchitis virus and its long-term effects on reproductive system development in SPF hens |
title | Pathogenicity evaluation of GVI-1 lineage infectious bronchitis virus and its long-term effects on reproductive system development in SPF hens |
title_full | Pathogenicity evaluation of GVI-1 lineage infectious bronchitis virus and its long-term effects on reproductive system development in SPF hens |
title_fullStr | Pathogenicity evaluation of GVI-1 lineage infectious bronchitis virus and its long-term effects on reproductive system development in SPF hens |
title_full_unstemmed | Pathogenicity evaluation of GVI-1 lineage infectious bronchitis virus and its long-term effects on reproductive system development in SPF hens |
title_short | Pathogenicity evaluation of GVI-1 lineage infectious bronchitis virus and its long-term effects on reproductive system development in SPF hens |
title_sort | pathogenicity evaluation of gvi-1 lineage infectious bronchitis virus and its long-term effects on reproductive system development in spf hens |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650418/ https://www.ncbi.nlm.nih.gov/pubmed/36386629 http://dx.doi.org/10.3389/fmicb.2022.1049287 |
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