Inhibition of colon cancer K-Ras(G13D) mutation reduces cancer cell proliferation but promotes stemness and inflammation via RAS/ERK pathway

K-Ras is a well-studied oncogene, and its mutation is frequently found in epithelial cancers like pancreas, lung, and colorectal cancers. Cancer cells harboring K-Ras mutations are difficult to treat due to the drug resistance and metastasis properties. Cancer stem cells (CSCs) are believed the majo...

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Detalles Bibliográficos
Autores principales: Qi, Yan, Zou, Hong, Zhao, XiaoHui, Kapeleris, Joanna, Monteiro, Michael, Li, Feng, Xu, Zhi Ping, Deng, Yizhen, Wu, Yanheng, Tang, Ying, Gu, Wenyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650442/
https://www.ncbi.nlm.nih.gov/pubmed/36386200
http://dx.doi.org/10.3389/fphar.2022.996053

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