Caspase activation counteracts interferon signaling after G2 checkpoint abrogation by ATR inhibition in irradiated human cancer cells

Recent studies suggest that inhibition of the ATR kinase can potentiate radiation-induced antitumor immune responses, but the extent and mechanisms of such responses in human cancers remain scarcely understood. We aimed to assess whether the ATR inhibitors VE822 and AZD6738, by abrogating the G2 che...

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Detalles Bibliográficos
Autores principales: Eek Mariampillai, Adrian, Hauge, Sissel, Øynebråten, Inger, Rødland, Gro Elise, Corthay, Alexandre, Syljuåsen, Randi G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650454/
https://www.ncbi.nlm.nih.gov/pubmed/36387237
http://dx.doi.org/10.3389/fonc.2022.981332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650454/
https://www.ncbi.nlm.nih.gov/pubmed/36387237
http://dx.doi.org/10.3389/fonc.2022.981332

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