Cargando…

Decisive diagnostic clue for infectious abdominal aortic aneurysm caused by Arthrobacter russicus in a diabetic elderly woman with renal dysfunction: A case report and literature review

Infectious aortic aneurysm (IAA) can be a rare but potentially fatal sequela of infectious inflammatory disease of the aortic wall with a high incidence of rupture. The definitive diagnosis is based on vascular imaging of the aneurysm using contrast-enhanced computed tomography (CE-CT) and identific...

Descripción completa

Detalles Bibliográficos
Autores principales: Yamamoto, Hiroyuki, Fukushima, Yasuto, Ikeda, Yoshihiko, Suda, Tomoyuki, Goto, Mieko, Isogai, Jun, Hashimoto, Toru, Takahashi, Takashi, Ogino, Hidemitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650533/
https://www.ncbi.nlm.nih.gov/pubmed/36386385
http://dx.doi.org/10.3389/fcvm.2022.1007213
_version_ 1784828042634330112
author Yamamoto, Hiroyuki
Fukushima, Yasuto
Ikeda, Yoshihiko
Suda, Tomoyuki
Goto, Mieko
Isogai, Jun
Hashimoto, Toru
Takahashi, Takashi
Ogino, Hidemitsu
author_facet Yamamoto, Hiroyuki
Fukushima, Yasuto
Ikeda, Yoshihiko
Suda, Tomoyuki
Goto, Mieko
Isogai, Jun
Hashimoto, Toru
Takahashi, Takashi
Ogino, Hidemitsu
author_sort Yamamoto, Hiroyuki
collection PubMed
description Infectious aortic aneurysm (IAA) can be a rare but potentially fatal sequela of infectious inflammatory disease of the aortic wall with a high incidence of rupture. The definitive diagnosis is based on vascular imaging of the aneurysm using contrast-enhanced computed tomography (CE-CT) and identification of the causative microorganism from positive blood cultures (BCs). However, IAA remains extremely difficult to diagnose and treat in patients with prior antimicrobial treatment or with renal dysfunction. Here we describe a case of an 85-year-old woman with IAA caused by Arthrobacter russicus presenting with abdominal pain and fever that was initially diagnosed as a presumptive urinary tract infection and treated with empiric antimicrobial therapy. However, persistent abdominal pain with increased serological inflammation necessitated further evaluation. Unenhanced multimodality imaging considering the renal dysfunction revealed infectious aortitis of the infrarenal abdominal aorta, together with the initial culture results, leading to the tentative diagnosis of Klebsiella pneumoniae aortitis. Thereafter, serial monitoring with unenhanced magnetic resonance angiography (MRA) using thin-slab maximum intensity projection (TS-MIP) revealed acute aortic expansion strongly suggestive of a pseudoaneurysm that was successfully treated with early surgical repair under adequate infection control. Despite negative Gram staining and tissue culture results for the excised aortic wall, a definitive diagnosis of IAA secondary to A. russicus rather than K. pneumoniae was finally made by confirming the histologic findings consistent with IAA and the identification of A. russicus 16S rRNA on the resected aortic wall. The patient also developed a vascular graft infection during the postoperative course that required long-term systemic antimicrobial therapy. This case highlights the value of unenhanced MRA in the early detection of IAA in patients with renal dysfunction and the importance of a molecular diagnosis for identifying the causative microorganism in cases of culture- or tissue-negative IAA.
format Online
Article
Text
id pubmed-9650533
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-96505332022-11-15 Decisive diagnostic clue for infectious abdominal aortic aneurysm caused by Arthrobacter russicus in a diabetic elderly woman with renal dysfunction: A case report and literature review Yamamoto, Hiroyuki Fukushima, Yasuto Ikeda, Yoshihiko Suda, Tomoyuki Goto, Mieko Isogai, Jun Hashimoto, Toru Takahashi, Takashi Ogino, Hidemitsu Front Cardiovasc Med Cardiovascular Medicine Infectious aortic aneurysm (IAA) can be a rare but potentially fatal sequela of infectious inflammatory disease of the aortic wall with a high incidence of rupture. The definitive diagnosis is based on vascular imaging of the aneurysm using contrast-enhanced computed tomography (CE-CT) and identification of the causative microorganism from positive blood cultures (BCs). However, IAA remains extremely difficult to diagnose and treat in patients with prior antimicrobial treatment or with renal dysfunction. Here we describe a case of an 85-year-old woman with IAA caused by Arthrobacter russicus presenting with abdominal pain and fever that was initially diagnosed as a presumptive urinary tract infection and treated with empiric antimicrobial therapy. However, persistent abdominal pain with increased serological inflammation necessitated further evaluation. Unenhanced multimodality imaging considering the renal dysfunction revealed infectious aortitis of the infrarenal abdominal aorta, together with the initial culture results, leading to the tentative diagnosis of Klebsiella pneumoniae aortitis. Thereafter, serial monitoring with unenhanced magnetic resonance angiography (MRA) using thin-slab maximum intensity projection (TS-MIP) revealed acute aortic expansion strongly suggestive of a pseudoaneurysm that was successfully treated with early surgical repair under adequate infection control. Despite negative Gram staining and tissue culture results for the excised aortic wall, a definitive diagnosis of IAA secondary to A. russicus rather than K. pneumoniae was finally made by confirming the histologic findings consistent with IAA and the identification of A. russicus 16S rRNA on the resected aortic wall. The patient also developed a vascular graft infection during the postoperative course that required long-term systemic antimicrobial therapy. This case highlights the value of unenhanced MRA in the early detection of IAA in patients with renal dysfunction and the importance of a molecular diagnosis for identifying the causative microorganism in cases of culture- or tissue-negative IAA. Frontiers Media S.A. 2022-10-28 /pmc/articles/PMC9650533/ /pubmed/36386385 http://dx.doi.org/10.3389/fcvm.2022.1007213 Text en Copyright © 2022 Yamamoto, Fukushima, Ikeda, Suda, Goto, Isogai, Hashimoto, Takahashi and Ogino. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Yamamoto, Hiroyuki
Fukushima, Yasuto
Ikeda, Yoshihiko
Suda, Tomoyuki
Goto, Mieko
Isogai, Jun
Hashimoto, Toru
Takahashi, Takashi
Ogino, Hidemitsu
Decisive diagnostic clue for infectious abdominal aortic aneurysm caused by Arthrobacter russicus in a diabetic elderly woman with renal dysfunction: A case report and literature review
title Decisive diagnostic clue for infectious abdominal aortic aneurysm caused by Arthrobacter russicus in a diabetic elderly woman with renal dysfunction: A case report and literature review
title_full Decisive diagnostic clue for infectious abdominal aortic aneurysm caused by Arthrobacter russicus in a diabetic elderly woman with renal dysfunction: A case report and literature review
title_fullStr Decisive diagnostic clue for infectious abdominal aortic aneurysm caused by Arthrobacter russicus in a diabetic elderly woman with renal dysfunction: A case report and literature review
title_full_unstemmed Decisive diagnostic clue for infectious abdominal aortic aneurysm caused by Arthrobacter russicus in a diabetic elderly woman with renal dysfunction: A case report and literature review
title_short Decisive diagnostic clue for infectious abdominal aortic aneurysm caused by Arthrobacter russicus in a diabetic elderly woman with renal dysfunction: A case report and literature review
title_sort decisive diagnostic clue for infectious abdominal aortic aneurysm caused by arthrobacter russicus in a diabetic elderly woman with renal dysfunction: a case report and literature review
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650533/
https://www.ncbi.nlm.nih.gov/pubmed/36386385
http://dx.doi.org/10.3389/fcvm.2022.1007213
work_keys_str_mv AT yamamotohiroyuki decisivediagnosticclueforinfectiousabdominalaorticaneurysmcausedbyarthrobacterrussicusinadiabeticelderlywomanwithrenaldysfunctionacasereportandliteraturereview
AT fukushimayasuto decisivediagnosticclueforinfectiousabdominalaorticaneurysmcausedbyarthrobacterrussicusinadiabeticelderlywomanwithrenaldysfunctionacasereportandliteraturereview
AT ikedayoshihiko decisivediagnosticclueforinfectiousabdominalaorticaneurysmcausedbyarthrobacterrussicusinadiabeticelderlywomanwithrenaldysfunctionacasereportandliteraturereview
AT sudatomoyuki decisivediagnosticclueforinfectiousabdominalaorticaneurysmcausedbyarthrobacterrussicusinadiabeticelderlywomanwithrenaldysfunctionacasereportandliteraturereview
AT gotomieko decisivediagnosticclueforinfectiousabdominalaorticaneurysmcausedbyarthrobacterrussicusinadiabeticelderlywomanwithrenaldysfunctionacasereportandliteraturereview
AT isogaijun decisivediagnosticclueforinfectiousabdominalaorticaneurysmcausedbyarthrobacterrussicusinadiabeticelderlywomanwithrenaldysfunctionacasereportandliteraturereview
AT hashimototoru decisivediagnosticclueforinfectiousabdominalaorticaneurysmcausedbyarthrobacterrussicusinadiabeticelderlywomanwithrenaldysfunctionacasereportandliteraturereview
AT takahashitakashi decisivediagnosticclueforinfectiousabdominalaorticaneurysmcausedbyarthrobacterrussicusinadiabeticelderlywomanwithrenaldysfunctionacasereportandliteraturereview
AT oginohidemitsu decisivediagnosticclueforinfectiousabdominalaorticaneurysmcausedbyarthrobacterrussicusinadiabeticelderlywomanwithrenaldysfunctionacasereportandliteraturereview