The impact of age-related hypomethylated DNA on immune signaling upon cellular demise

Aging is associated with decreased antigen-specific immunity and increased chronic inflammation. While DNA-sensing pathways might be involved, the molecular factors underlying these age-related aberrancies in immune signaling are unclear. Here, we consider the potential role of aging-induced hypomet...

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Detalles Bibliográficos
Autores principales: Urban, Lauren A., Trinh, Annie, Pearlman, Eric, Siryaporn, Albert, Downing, Timothy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650629/
https://www.ncbi.nlm.nih.gov/pubmed/33994111
http://dx.doi.org/10.1016/j.it.2021.04.005
Descripción
Sumario:Aging is associated with decreased antigen-specific immunity and increased chronic inflammation. While DNA-sensing pathways might be involved, the molecular factors underlying these age-related aberrancies in immune signaling are unclear. Here, we consider the potential role of aging-induced hypomethylated DNA as a putative stimulant of age-associated inflammation.

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