The impact of age-related hypomethylated DNA on immune signaling upon cellular demise

Aging is associated with decreased antigen-specific immunity and increased chronic inflammation. While DNA-sensing pathways might be involved, the molecular factors underlying these age-related aberrancies in immune signaling are unclear. Here, we consider the potential role of aging-induced hypomet...

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Autores principales: Urban, Lauren A., Trinh, Annie, Pearlman, Eric, Siryaporn, Albert, Downing, Timothy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650629/
https://www.ncbi.nlm.nih.gov/pubmed/33994111
http://dx.doi.org/10.1016/j.it.2021.04.005
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author Urban, Lauren A.
Trinh, Annie
Pearlman, Eric
Siryaporn, Albert
Downing, Timothy L.
author_facet Urban, Lauren A.
Trinh, Annie
Pearlman, Eric
Siryaporn, Albert
Downing, Timothy L.
author_sort Urban, Lauren A.
collection PubMed
description Aging is associated with decreased antigen-specific immunity and increased chronic inflammation. While DNA-sensing pathways might be involved, the molecular factors underlying these age-related aberrancies in immune signaling are unclear. Here, we consider the potential role of aging-induced hypomethylated DNA as a putative stimulant of age-associated inflammation.
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spelling pubmed-96506292022-11-14 The impact of age-related hypomethylated DNA on immune signaling upon cellular demise Urban, Lauren A. Trinh, Annie Pearlman, Eric Siryaporn, Albert Downing, Timothy L. Trends Immunol Article Aging is associated with decreased antigen-specific immunity and increased chronic inflammation. While DNA-sensing pathways might be involved, the molecular factors underlying these age-related aberrancies in immune signaling are unclear. Here, we consider the potential role of aging-induced hypomethylated DNA as a putative stimulant of age-associated inflammation. 2021-06 2021-05-11 /pmc/articles/PMC9650629/ /pubmed/33994111 http://dx.doi.org/10.1016/j.it.2021.04.005 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Urban, Lauren A.
Trinh, Annie
Pearlman, Eric
Siryaporn, Albert
Downing, Timothy L.
The impact of age-related hypomethylated DNA on immune signaling upon cellular demise
title The impact of age-related hypomethylated DNA on immune signaling upon cellular demise
title_full The impact of age-related hypomethylated DNA on immune signaling upon cellular demise
title_fullStr The impact of age-related hypomethylated DNA on immune signaling upon cellular demise
title_full_unstemmed The impact of age-related hypomethylated DNA on immune signaling upon cellular demise
title_short The impact of age-related hypomethylated DNA on immune signaling upon cellular demise
title_sort impact of age-related hypomethylated dna on immune signaling upon cellular demise
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650629/
https://www.ncbi.nlm.nih.gov/pubmed/33994111
http://dx.doi.org/10.1016/j.it.2021.04.005
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