Exploiting the role of T cells in the pathogenesis of Sjögren’s syndrome for therapeutic treatment

Sjögrens syndrome (SS) is caused by autoantibodies that attack proprioceptive salivary and lacrimal gland tissues. Damage to the glands leads to dry mouth and eyes and affects multiple systems and organs. In severe cases, SS is life-threatening because it can lead to interstitial lung disease, renal...

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Autores principales: An, Qi, Zhao, Jingwen, Zhu, Xueqing, Yang, Baoqi, Wu, Zewen, Su, Yazhen, Zhang, Liyun, Xu, Ke, Ma, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650646/
https://www.ncbi.nlm.nih.gov/pubmed/36389806
http://dx.doi.org/10.3389/fimmu.2022.995895
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author An, Qi
Zhao, Jingwen
Zhu, Xueqing
Yang, Baoqi
Wu, Zewen
Su, Yazhen
Zhang, Liyun
Xu, Ke
Ma, Dan
author_facet An, Qi
Zhao, Jingwen
Zhu, Xueqing
Yang, Baoqi
Wu, Zewen
Su, Yazhen
Zhang, Liyun
Xu, Ke
Ma, Dan
author_sort An, Qi
collection PubMed
description Sjögrens syndrome (SS) is caused by autoantibodies that attack proprioceptive salivary and lacrimal gland tissues. Damage to the glands leads to dry mouth and eyes and affects multiple systems and organs. In severe cases, SS is life-threatening because it can lead to interstitial lung disease, renal insufficiency, and lymphoma. Histological examination of the labial minor salivary glands of patients with SS reveals focal lymphocyte aggregation of T and B cells. More studies have been conducted on the role of B cells in the pathogenesis of SS, whereas the role of T cells has only recently attracted the attention of researchers. This review focusses on the role of various populations of T cells in the pathogenesis of SS and the progress made in research to therapeutically targeting T cells for the treatment of patients with SS.
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spelling pubmed-96506462022-11-15 Exploiting the role of T cells in the pathogenesis of Sjögren’s syndrome for therapeutic treatment An, Qi Zhao, Jingwen Zhu, Xueqing Yang, Baoqi Wu, Zewen Su, Yazhen Zhang, Liyun Xu, Ke Ma, Dan Front Immunol Immunology Sjögrens syndrome (SS) is caused by autoantibodies that attack proprioceptive salivary and lacrimal gland tissues. Damage to the glands leads to dry mouth and eyes and affects multiple systems and organs. In severe cases, SS is life-threatening because it can lead to interstitial lung disease, renal insufficiency, and lymphoma. Histological examination of the labial minor salivary glands of patients with SS reveals focal lymphocyte aggregation of T and B cells. More studies have been conducted on the role of B cells in the pathogenesis of SS, whereas the role of T cells has only recently attracted the attention of researchers. This review focusses on the role of various populations of T cells in the pathogenesis of SS and the progress made in research to therapeutically targeting T cells for the treatment of patients with SS. Frontiers Media S.A. 2022-10-28 /pmc/articles/PMC9650646/ /pubmed/36389806 http://dx.doi.org/10.3389/fimmu.2022.995895 Text en Copyright © 2022 An, Zhao, Zhu, Yang, Wu, Su, Zhang, Xu and Ma https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
An, Qi
Zhao, Jingwen
Zhu, Xueqing
Yang, Baoqi
Wu, Zewen
Su, Yazhen
Zhang, Liyun
Xu, Ke
Ma, Dan
Exploiting the role of T cells in the pathogenesis of Sjögren’s syndrome for therapeutic treatment
title Exploiting the role of T cells in the pathogenesis of Sjögren’s syndrome for therapeutic treatment
title_full Exploiting the role of T cells in the pathogenesis of Sjögren’s syndrome for therapeutic treatment
title_fullStr Exploiting the role of T cells in the pathogenesis of Sjögren’s syndrome for therapeutic treatment
title_full_unstemmed Exploiting the role of T cells in the pathogenesis of Sjögren’s syndrome for therapeutic treatment
title_short Exploiting the role of T cells in the pathogenesis of Sjögren’s syndrome for therapeutic treatment
title_sort exploiting the role of t cells in the pathogenesis of sjögren’s syndrome for therapeutic treatment
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650646/
https://www.ncbi.nlm.nih.gov/pubmed/36389806
http://dx.doi.org/10.3389/fimmu.2022.995895
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