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Biomimetic lung-on-a-chip to model virus infection and drug evaluation
Viral infectious diseases remain a global public health problem. The rapid and widespread spread of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV‑2) has had a severe impact on the global economy and human activities, highlighting the vulnerab...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s). Published by Elsevier B.V.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650675/ https://www.ncbi.nlm.nih.gov/pubmed/36375766 http://dx.doi.org/10.1016/j.ejps.2022.106329 |
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author | Tan, Jianfeng Guo, Quanwei Tian, Lingling Pei, Zhendong Li, Dongfang Wu, Mengxi Zhang, Jianhua Gao, Xinghua |
author_facet | Tan, Jianfeng Guo, Quanwei Tian, Lingling Pei, Zhendong Li, Dongfang Wu, Mengxi Zhang, Jianhua Gao, Xinghua |
author_sort | Tan, Jianfeng |
collection | PubMed |
description | Viral infectious diseases remain a global public health problem. The rapid and widespread spread of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV‑2) has had a severe impact on the global economy and human activities, highlighting the vulnerability of humans to viral infectious diseases and the urgent need to develop new technologies and effective treatments. Organ-on-a-chip is an emerging technology for constructing the physiological and pathological microenvironment of human organs in vitro and has the advantages of portability, high throughput, low cost, and accurate simulation of the in vivo microenvironment. Indeed, organ-on-a-chip provides a low-cost alternative for investigating human organ physiology, organ diseases, toxicology, and drug efficacy. The lung is a main target organ of viral infection, and lung pathophysiology must be assessed after viral infection and treatment with antiviral drugs. This review introduces the construction of lung-on-a-chip and its related pathophysiological models, focusing on the in vitro simulation of viral infection and evaluation of antiviral drugs, providing a developmental direction for research and treatment of viral diseases. |
format | Online Article Text |
id | pubmed-9650675 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Author(s). Published by Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96506752022-11-14 Biomimetic lung-on-a-chip to model virus infection and drug evaluation Tan, Jianfeng Guo, Quanwei Tian, Lingling Pei, Zhendong Li, Dongfang Wu, Mengxi Zhang, Jianhua Gao, Xinghua Eur J Pharm Sci Article Viral infectious diseases remain a global public health problem. The rapid and widespread spread of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV‑2) has had a severe impact on the global economy and human activities, highlighting the vulnerability of humans to viral infectious diseases and the urgent need to develop new technologies and effective treatments. Organ-on-a-chip is an emerging technology for constructing the physiological and pathological microenvironment of human organs in vitro and has the advantages of portability, high throughput, low cost, and accurate simulation of the in vivo microenvironment. Indeed, organ-on-a-chip provides a low-cost alternative for investigating human organ physiology, organ diseases, toxicology, and drug efficacy. The lung is a main target organ of viral infection, and lung pathophysiology must be assessed after viral infection and treatment with antiviral drugs. This review introduces the construction of lung-on-a-chip and its related pathophysiological models, focusing on the in vitro simulation of viral infection and evaluation of antiviral drugs, providing a developmental direction for research and treatment of viral diseases. The Author(s). Published by Elsevier B.V. 2023-01-01 2022-11-11 /pmc/articles/PMC9650675/ /pubmed/36375766 http://dx.doi.org/10.1016/j.ejps.2022.106329 Text en © 2022 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Tan, Jianfeng Guo, Quanwei Tian, Lingling Pei, Zhendong Li, Dongfang Wu, Mengxi Zhang, Jianhua Gao, Xinghua Biomimetic lung-on-a-chip to model virus infection and drug evaluation |
title | Biomimetic lung-on-a-chip to model virus infection and drug evaluation |
title_full | Biomimetic lung-on-a-chip to model virus infection and drug evaluation |
title_fullStr | Biomimetic lung-on-a-chip to model virus infection and drug evaluation |
title_full_unstemmed | Biomimetic lung-on-a-chip to model virus infection and drug evaluation |
title_short | Biomimetic lung-on-a-chip to model virus infection and drug evaluation |
title_sort | biomimetic lung-on-a-chip to model virus infection and drug evaluation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650675/ https://www.ncbi.nlm.nih.gov/pubmed/36375766 http://dx.doi.org/10.1016/j.ejps.2022.106329 |
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