De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors

[Image: see text] Bioengineering of ribosomally synthesized and post-translationally modified peptides (RiPPs) is an emerging approach to explore the diversity of pseudo-natural product structures for drug discovery purposes. However, despite the initial advances in this area, bioactivity reprogramm...

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Detalles Bibliográficos
Autores principales: Vinogradov, Alexander A., Zhang, Yue, Hamada, Keisuke, Chang, Jun Shi, Okada, Chikako, Nishimura, Hirotaka, Terasaka, Naohiro, Goto, Yuki, Ogata, Kazuhiro, Sengoku, Toru, Onaka, Hiroyasu, Suga, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650704/
https://www.ncbi.nlm.nih.gov/pubmed/36282922
http://dx.doi.org/10.1021/jacs.2c07937

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650704/
https://www.ncbi.nlm.nih.gov/pubmed/36282922
http://dx.doi.org/10.1021/jacs.2c07937

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