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Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of l-type amino acid transporter 1

BACKGROUND: Cancer-upregulated l-type amino acid transporter 1 (LAT1; SLC7A5) supplies essential amino acids to cancer cells. LAT1 substrates are not only needed for cancer rapid growth, but involved in cellular signaling. LAT1 has been proposed as a potential target for cancer treatment—its inhibit...

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Detalles Bibliográficos
Autores principales:	Okanishi, Hiroki, Ohgaki, Ryuichi, Xu, Minhui, Endou, Hitoshi, Kanai, Yoshikatsu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650822/ https://www.ncbi.nlm.nih.gov/pubmed/36357940 http://dx.doi.org/10.1186/s40170-022-00295-8

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