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Real-World Cost of Nasal Polyps Surgery and Risk of Major Complications in the United States: A Descriptive Retrospective Database Analysis

BACKGROUND: Endoscopic nasal polyp (NP) surgery is a treatment option for patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Previous studies report NP surgery costs of $8000–13,000 and risk of major complications of NP surgery of ~0.1–1%. Limited contemporary data for costs and compli...

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Autores principales: Ge, Wenzhen, Wang, Degang, Chuang, Chien-Chia, Li, Yongtao, Rout, Raj, Siddiqui, Shahid, Kamat, Siddhesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651015/
https://www.ncbi.nlm.nih.gov/pubmed/36389100
http://dx.doi.org/10.2147/CEOR.S380411
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author Ge, Wenzhen
Wang, Degang
Chuang, Chien-Chia
Li, Yongtao
Rout, Raj
Siddiqui, Shahid
Kamat, Siddhesh
author_facet Ge, Wenzhen
Wang, Degang
Chuang, Chien-Chia
Li, Yongtao
Rout, Raj
Siddiqui, Shahid
Kamat, Siddhesh
author_sort Ge, Wenzhen
collection PubMed
description BACKGROUND: Endoscopic nasal polyp (NP) surgery is a treatment option for patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Previous studies report NP surgery costs of $8000–13,000 and risk of major complications of NP surgery of ~0.1–1%. Limited contemporary data for costs and complications associated with NP surgery in US clinical practice are available. METHODS: IQVIA PharMetrics Plus claims data were used to identify patients with NP surgery in 2019 with ≥3 years continuous baseline health-plan enrollment prior to index date (date of first eligible NP surgery) and ≥30 days continuous enrollment after index (follow-up). In this descriptive analysis, total costs of NP surgery were estimated as all medical costs on the index date (or during the entire hospital stay for patients who received surgery in the inpatient setting). Total medical costs (all-cause) were estimated for all medical services occurring from the index date to the index date +9 or +29 days (10-day and 30-day). Major complication was defined as cerebrospinal fluid (CSF) leak, orbital injury, or major hemorrhage within 30 days of index. RESULTS: Of 6311 patients, median age was 46 years (interquartile range: 34–56); 59.7% were male; 88.2% had no NP surgery in the prior 3 years; 63.7% had allergic rhinitis, and 37.1% had asthma. Mean (SD) total medical cost of surgery was $14,697 (11,679) and mean (SD) 10-day total medical cost was $15,401 (11,968). Major complications occurred in 102 (1.7%) patients. Total medical costs and 10-day costs were higher in patients with major complications than those without ($23,605 [19,264] vs $15,251 [11,741]). CONCLUSION: In this descriptive analysis, NP surgery costs and rates of major surgical complications were updated using recent real-world data in the US. Results indicated that NP surgery complication rates were numerically higher than previously reported.
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spelling pubmed-96510152022-11-15 Real-World Cost of Nasal Polyps Surgery and Risk of Major Complications in the United States: A Descriptive Retrospective Database Analysis Ge, Wenzhen Wang, Degang Chuang, Chien-Chia Li, Yongtao Rout, Raj Siddiqui, Shahid Kamat, Siddhesh Clinicoecon Outcomes Res Original Research BACKGROUND: Endoscopic nasal polyp (NP) surgery is a treatment option for patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Previous studies report NP surgery costs of $8000–13,000 and risk of major complications of NP surgery of ~0.1–1%. Limited contemporary data for costs and complications associated with NP surgery in US clinical practice are available. METHODS: IQVIA PharMetrics Plus claims data were used to identify patients with NP surgery in 2019 with ≥3 years continuous baseline health-plan enrollment prior to index date (date of first eligible NP surgery) and ≥30 days continuous enrollment after index (follow-up). In this descriptive analysis, total costs of NP surgery were estimated as all medical costs on the index date (or during the entire hospital stay for patients who received surgery in the inpatient setting). Total medical costs (all-cause) were estimated for all medical services occurring from the index date to the index date +9 or +29 days (10-day and 30-day). Major complication was defined as cerebrospinal fluid (CSF) leak, orbital injury, or major hemorrhage within 30 days of index. RESULTS: Of 6311 patients, median age was 46 years (interquartile range: 34–56); 59.7% were male; 88.2% had no NP surgery in the prior 3 years; 63.7% had allergic rhinitis, and 37.1% had asthma. Mean (SD) total medical cost of surgery was $14,697 (11,679) and mean (SD) 10-day total medical cost was $15,401 (11,968). Major complications occurred in 102 (1.7%) patients. Total medical costs and 10-day costs were higher in patients with major complications than those without ($23,605 [19,264] vs $15,251 [11,741]). CONCLUSION: In this descriptive analysis, NP surgery costs and rates of major surgical complications were updated using recent real-world data in the US. Results indicated that NP surgery complication rates were numerically higher than previously reported. Dove 2022-11-07 /pmc/articles/PMC9651015/ /pubmed/36389100 http://dx.doi.org/10.2147/CEOR.S380411 Text en © 2022 Ge et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Ge, Wenzhen
Wang, Degang
Chuang, Chien-Chia
Li, Yongtao
Rout, Raj
Siddiqui, Shahid
Kamat, Siddhesh
Real-World Cost of Nasal Polyps Surgery and Risk of Major Complications in the United States: A Descriptive Retrospective Database Analysis
title Real-World Cost of Nasal Polyps Surgery and Risk of Major Complications in the United States: A Descriptive Retrospective Database Analysis
title_full Real-World Cost of Nasal Polyps Surgery and Risk of Major Complications in the United States: A Descriptive Retrospective Database Analysis
title_fullStr Real-World Cost of Nasal Polyps Surgery and Risk of Major Complications in the United States: A Descriptive Retrospective Database Analysis
title_full_unstemmed Real-World Cost of Nasal Polyps Surgery and Risk of Major Complications in the United States: A Descriptive Retrospective Database Analysis
title_short Real-World Cost of Nasal Polyps Surgery and Risk of Major Complications in the United States: A Descriptive Retrospective Database Analysis
title_sort real-world cost of nasal polyps surgery and risk of major complications in the united states: a descriptive retrospective database analysis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651015/
https://www.ncbi.nlm.nih.gov/pubmed/36389100
http://dx.doi.org/10.2147/CEOR.S380411
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