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Enteropathy Markers in Early Life Were Associated with Adipokine, Apolipoprotein, and Cytokine Profiles Consistent with an Adverse Cardiometabolic Disease Risk Profile Later in Childhood in a Peruvian Birth Cohort

Metabolic syndrome is a cluster of risk factors for cardiovascular disease afflicting more than 1 billion people worldwide and is increasingly being identified in younger age groups and in socioeconomically disadvantaged settings in the global south. Enteropathogen exposure and environmental enterop...

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Autores principales: Colston, Josh M., Chen, Yen Ting, Hinson, Patrick, Nguyen, Nhat-Lan H., Peñataro Yori, Pablo, Olortegui, Maribel Paredes, Rengifo Trigoso, Dixner, Siguas Salas, Mery, Guerrant, Richard L., François, Ruthly, Kosek, Margaret N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651527/
https://www.ncbi.nlm.nih.gov/pubmed/36096405
http://dx.doi.org/10.4269/ajtmh.21-1024
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author Colston, Josh M.
Chen, Yen Ting
Hinson, Patrick
Nguyen, Nhat-Lan H.
Peñataro Yori, Pablo
Olortegui, Maribel Paredes
Rengifo Trigoso, Dixner
Siguas Salas, Mery
Guerrant, Richard L.
François, Ruthly
Kosek, Margaret N.
author_facet Colston, Josh M.
Chen, Yen Ting
Hinson, Patrick
Nguyen, Nhat-Lan H.
Peñataro Yori, Pablo
Olortegui, Maribel Paredes
Rengifo Trigoso, Dixner
Siguas Salas, Mery
Guerrant, Richard L.
François, Ruthly
Kosek, Margaret N.
author_sort Colston, Josh M.
collection PubMed
description Metabolic syndrome is a cluster of risk factors for cardiovascular disease afflicting more than 1 billion people worldwide and is increasingly being identified in younger age groups and in socioeconomically disadvantaged settings in the global south. Enteropathogen exposure and environmental enteropathy in infancy may contribute to metabolic syndrome by disrupting the metabolic profile in a way that is detectable in cardiometabolic markers later in childhood. A total of 217 subjects previously enrolled in a birth cohort in Amazonian Peru were monitored annually from ages 2 to 5 years. A total of 197 blood samples collected in later childhood were analyzed for 37 cardiometabolic biomarkers, including adipokines, apolipoproteins, cytokines, which were matched to extant early-life markers of enteropathy ascertained between birth and 2 years. Multivariate and multivariable regression models were fitted to test for associations, adjusting for confounders. Fecal and urinary markers of intestinal permeability and inflammation (myeloperoxidase, lactulose, and mannitol) measured in infancy were associated with later serum concentrations of soluble CD40-ligand, a proinflammatory cytokine correlated with adverse metabolic outcomes. Fecal myeloperoxidase was also associated with later levels of omentin-1. Enteric protozoa exposure showed stronger associations with later cardiometabolic markers than viruses, bacteria, and overall diarrheal episodes. Early-life enteropathy markers were associated with altered adipokine, apolipoprotein, and cytokine profiles later in childhood consistent with an adverse cardiometabolic disease risk profile in this cohort. Markers of intestinal permeability and inflammation measured in urine (lactulose, mannitol) and stool (myeloperoxidase, protozoal infections) during infancy may predict metabolic syndrome in adulthood.
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spelling pubmed-96515272022-11-18 Enteropathy Markers in Early Life Were Associated with Adipokine, Apolipoprotein, and Cytokine Profiles Consistent with an Adverse Cardiometabolic Disease Risk Profile Later in Childhood in a Peruvian Birth Cohort Colston, Josh M. Chen, Yen Ting Hinson, Patrick Nguyen, Nhat-Lan H. Peñataro Yori, Pablo Olortegui, Maribel Paredes Rengifo Trigoso, Dixner Siguas Salas, Mery Guerrant, Richard L. François, Ruthly Kosek, Margaret N. Am J Trop Med Hyg Research Article Metabolic syndrome is a cluster of risk factors for cardiovascular disease afflicting more than 1 billion people worldwide and is increasingly being identified in younger age groups and in socioeconomically disadvantaged settings in the global south. Enteropathogen exposure and environmental enteropathy in infancy may contribute to metabolic syndrome by disrupting the metabolic profile in a way that is detectable in cardiometabolic markers later in childhood. A total of 217 subjects previously enrolled in a birth cohort in Amazonian Peru were monitored annually from ages 2 to 5 years. A total of 197 blood samples collected in later childhood were analyzed for 37 cardiometabolic biomarkers, including adipokines, apolipoproteins, cytokines, which were matched to extant early-life markers of enteropathy ascertained between birth and 2 years. Multivariate and multivariable regression models were fitted to test for associations, adjusting for confounders. Fecal and urinary markers of intestinal permeability and inflammation (myeloperoxidase, lactulose, and mannitol) measured in infancy were associated with later serum concentrations of soluble CD40-ligand, a proinflammatory cytokine correlated with adverse metabolic outcomes. Fecal myeloperoxidase was also associated with later levels of omentin-1. Enteric protozoa exposure showed stronger associations with later cardiometabolic markers than viruses, bacteria, and overall diarrheal episodes. Early-life enteropathy markers were associated with altered adipokine, apolipoprotein, and cytokine profiles later in childhood consistent with an adverse cardiometabolic disease risk profile in this cohort. Markers of intestinal permeability and inflammation measured in urine (lactulose, mannitol) and stool (myeloperoxidase, protozoal infections) during infancy may predict metabolic syndrome in adulthood. The American Society of Tropical Medicine and Hygiene 2022-10 2022-09-12 /pmc/articles/PMC9651527/ /pubmed/36096405 http://dx.doi.org/10.4269/ajtmh.21-1024 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Colston, Josh M.
Chen, Yen Ting
Hinson, Patrick
Nguyen, Nhat-Lan H.
Peñataro Yori, Pablo
Olortegui, Maribel Paredes
Rengifo Trigoso, Dixner
Siguas Salas, Mery
Guerrant, Richard L.
François, Ruthly
Kosek, Margaret N.
Enteropathy Markers in Early Life Were Associated with Adipokine, Apolipoprotein, and Cytokine Profiles Consistent with an Adverse Cardiometabolic Disease Risk Profile Later in Childhood in a Peruvian Birth Cohort
title Enteropathy Markers in Early Life Were Associated with Adipokine, Apolipoprotein, and Cytokine Profiles Consistent with an Adverse Cardiometabolic Disease Risk Profile Later in Childhood in a Peruvian Birth Cohort
title_full Enteropathy Markers in Early Life Were Associated with Adipokine, Apolipoprotein, and Cytokine Profiles Consistent with an Adverse Cardiometabolic Disease Risk Profile Later in Childhood in a Peruvian Birth Cohort
title_fullStr Enteropathy Markers in Early Life Were Associated with Adipokine, Apolipoprotein, and Cytokine Profiles Consistent with an Adverse Cardiometabolic Disease Risk Profile Later in Childhood in a Peruvian Birth Cohort
title_full_unstemmed Enteropathy Markers in Early Life Were Associated with Adipokine, Apolipoprotein, and Cytokine Profiles Consistent with an Adverse Cardiometabolic Disease Risk Profile Later in Childhood in a Peruvian Birth Cohort
title_short Enteropathy Markers in Early Life Were Associated with Adipokine, Apolipoprotein, and Cytokine Profiles Consistent with an Adverse Cardiometabolic Disease Risk Profile Later in Childhood in a Peruvian Birth Cohort
title_sort enteropathy markers in early life were associated with adipokine, apolipoprotein, and cytokine profiles consistent with an adverse cardiometabolic disease risk profile later in childhood in a peruvian birth cohort
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651527/
https://www.ncbi.nlm.nih.gov/pubmed/36096405
http://dx.doi.org/10.4269/ajtmh.21-1024
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