RNase L activation in the cytoplasm induces aberrant processing of mRNAs in the nucleus

The antiviral endoribonuclease, RNase L, is activated by the mammalian innate immune response to destroy host and viral RNA to ultimately reduce viral gene expression. Herein, we show that RNase L and RNase L-mediated mRNA decay are primarily localized to the cytoplasm. Consequently, RNA-binding pro...

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Detalles Bibliográficos
Autores principales: Burke, James M., Ripin, Nina, Ferretti, Max B., St Clair, Laura A., Worden-Sapper, Emma R., Salgado, Fernando, Sawyer, Sara L., Perera, Rushika, Lynch, Kristen W., Parker, Roy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651596/
https://www.ncbi.nlm.nih.gov/pubmed/36318584
http://dx.doi.org/10.1371/journal.ppat.1010930

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