Pancreatic tumor microenvironmental acidosis and hypoxia transform gold nanorods into cell-penetrant particles for potent radiosensitization

Coating nanoparticles with stealth epilayers increases circulation time by evading opsonization, macrophage phagocytosis, and reticuloendothelial sequestration. However, this also reduces internalization by cancer cells upon reaching the tumor. We designed gold nanorods (GNRs) with an epilayer that...

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Detalles Bibliográficos
Autores principales: Rauta, Pradipta Ranjan, Mackeyev, Yuri, Sanders, Keith, Kim, Joseph B.K., Gonzalez, Valeria V., Zahra, Yasmin, Shohayeb, Muhammad A., Abousaida, Belal, Vijay, Geraldine V., Tezcan, Okan, Derry, Paul, Liopo, Anton V., Zubarev, Eugene R., Carter, Rickey, Singh, Pankaj, Krishnan, Sunil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651859/
https://www.ncbi.nlm.nih.gov/pubmed/36367938
http://dx.doi.org/10.1126/sciadv.abm9729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651859/
https://www.ncbi.nlm.nih.gov/pubmed/36367938
http://dx.doi.org/10.1126/sciadv.abm9729

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