Disulfiram ameliorates nonalcoholic steatohepatitis by modulating the gut microbiota and bile acid metabolism

Nonalcoholic steatohepatitis (NASH) has been linked with the gut-liver axis. Here, we investigate the potential for repurposing disulfiram (DSF), a drug commonly used to treat chronic alcoholism, for NASH. Using a mouse model, we show that DSF ameliorates NASH in a gut microbiota-dependent manner. D...

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Detalles Bibliográficos
Autores principales: Lei, Yuanyuan, Tang, Li, Chen, Qiao, Wu, Lingyi, He, Wei, Tu, Dianji, Wang, Sumin, Chen, Yuyang, Liu, Shuang, Xie, Zhuo, Wei, Hong, Yang, Shiming, Tang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651870/
https://www.ncbi.nlm.nih.gov/pubmed/36369291
http://dx.doi.org/10.1038/s41467-022-34671-1

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