Nanosystems for chemodynamic based combination therapy: Strategies and recent advances

Chemodynamic therapy (CDT), a newly developed approach for cancer treatment, can convert hydrogen peroxide (H(2)O(2)) into toxic hydroxyl radicals (•OH) by using Fenton/Fenton-like reaction to kill tumor cells. However, due to the complexity of the intracellular environment of tumor cells, the thera...

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Autores principales: Li, Minghui, Zhang, Wen, Xu, Xiaopeng, Liu, Guoying, Dong, Mengfei, Sun, Kaoxiang, Zhang, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651923/
https://www.ncbi.nlm.nih.gov/pubmed/36386143
http://dx.doi.org/10.3389/fphar.2022.1065438
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author Li, Minghui
Zhang, Wen
Xu, Xiaopeng
Liu, Guoying
Dong, Mengfei
Sun, Kaoxiang
Zhang, Peng
author_facet Li, Minghui
Zhang, Wen
Xu, Xiaopeng
Liu, Guoying
Dong, Mengfei
Sun, Kaoxiang
Zhang, Peng
author_sort Li, Minghui
collection PubMed
description Chemodynamic therapy (CDT), a newly developed approach for cancer treatment, can convert hydrogen peroxide (H(2)O(2)) into toxic hydroxyl radicals (•OH) by using Fenton/Fenton-like reaction to kill tumor cells. However, due to the complexity of the intracellular environment of tumor cells, the therapeutic efficacy of CDT was severely restricted. Recently, combination therapy strategies have become popular approaches for tumor treatment, and there are numerous studies have demonstrated that the CDT-based combination strategies can significantly improve the anti-tumor efficiency of CDT. In this review, we outline some of the recent progress in cancer chemodynamic therapy from 2020, and discuss the progress in the design of nanosystems for CDT synergistic combination therapies.
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spelling pubmed-96519232022-11-15 Nanosystems for chemodynamic based combination therapy: Strategies and recent advances Li, Minghui Zhang, Wen Xu, Xiaopeng Liu, Guoying Dong, Mengfei Sun, Kaoxiang Zhang, Peng Front Pharmacol Pharmacology Chemodynamic therapy (CDT), a newly developed approach for cancer treatment, can convert hydrogen peroxide (H(2)O(2)) into toxic hydroxyl radicals (•OH) by using Fenton/Fenton-like reaction to kill tumor cells. However, due to the complexity of the intracellular environment of tumor cells, the therapeutic efficacy of CDT was severely restricted. Recently, combination therapy strategies have become popular approaches for tumor treatment, and there are numerous studies have demonstrated that the CDT-based combination strategies can significantly improve the anti-tumor efficiency of CDT. In this review, we outline some of the recent progress in cancer chemodynamic therapy from 2020, and discuss the progress in the design of nanosystems for CDT synergistic combination therapies. Frontiers Media S.A. 2022-10-28 /pmc/articles/PMC9651923/ /pubmed/36386143 http://dx.doi.org/10.3389/fphar.2022.1065438 Text en Copyright © 2022 Li, Zhang, Xu, Liu, Dong, Sun and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Li, Minghui
Zhang, Wen
Xu, Xiaopeng
Liu, Guoying
Dong, Mengfei
Sun, Kaoxiang
Zhang, Peng
Nanosystems for chemodynamic based combination therapy: Strategies and recent advances
title Nanosystems for chemodynamic based combination therapy: Strategies and recent advances
title_full Nanosystems for chemodynamic based combination therapy: Strategies and recent advances
title_fullStr Nanosystems for chemodynamic based combination therapy: Strategies and recent advances
title_full_unstemmed Nanosystems for chemodynamic based combination therapy: Strategies and recent advances
title_short Nanosystems for chemodynamic based combination therapy: Strategies and recent advances
title_sort nanosystems for chemodynamic based combination therapy: strategies and recent advances
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651923/
https://www.ncbi.nlm.nih.gov/pubmed/36386143
http://dx.doi.org/10.3389/fphar.2022.1065438
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