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Nucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction error
There is active debate on the role of dopamine in processing aversive stimuli, where inferred roles range from no involvement at all, to signaling an aversive prediction error (APE). Here, we systematically investigate dopamine release in the nucleus accumbens core (NAC), which is closely linked to...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651945/ https://www.ncbi.nlm.nih.gov/pubmed/36366962 http://dx.doi.org/10.7554/eLife.82711 |
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author | Goedhoop, Jessica N van den Boom, Bastijn JG Robke, Rhiannon Veen, Felice Fellinger, Lizz van Elzelingen, Wouter Arbab, Tara Willuhn, Ingo |
author_facet | Goedhoop, Jessica N van den Boom, Bastijn JG Robke, Rhiannon Veen, Felice Fellinger, Lizz van Elzelingen, Wouter Arbab, Tara Willuhn, Ingo |
author_sort | Goedhoop, Jessica N |
collection | PubMed |
description | There is active debate on the role of dopamine in processing aversive stimuli, where inferred roles range from no involvement at all, to signaling an aversive prediction error (APE). Here, we systematically investigate dopamine release in the nucleus accumbens core (NAC), which is closely linked to reward prediction errors, in rats exposed to white noise (WN, a versatile, underutilized, aversive stimulus) and its predictive cues. Both induced a negative dopamine ramp, followed by slow signal recovery upon stimulus cessation. In contrast to reward conditioning, this dopamine signal was unaffected by WN value, context valence, or probabilistic contingencies, and the WN dopamine response shifted only partially toward its predictive cue. However, unpredicted WN provoked slower post-stimulus signal recovery than predicted WN. Despite differing signal qualities, dopamine responses to simultaneous presentation of rewarding and aversive stimuli were additive. Together, our findings demonstrate that instead of an APE, NAC dopamine primarily tracks prediction and duration of aversive events. |
format | Online Article Text |
id | pubmed-9651945 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-96519452022-11-15 Nucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction error Goedhoop, Jessica N van den Boom, Bastijn JG Robke, Rhiannon Veen, Felice Fellinger, Lizz van Elzelingen, Wouter Arbab, Tara Willuhn, Ingo eLife Neuroscience There is active debate on the role of dopamine in processing aversive stimuli, where inferred roles range from no involvement at all, to signaling an aversive prediction error (APE). Here, we systematically investigate dopamine release in the nucleus accumbens core (NAC), which is closely linked to reward prediction errors, in rats exposed to white noise (WN, a versatile, underutilized, aversive stimulus) and its predictive cues. Both induced a negative dopamine ramp, followed by slow signal recovery upon stimulus cessation. In contrast to reward conditioning, this dopamine signal was unaffected by WN value, context valence, or probabilistic contingencies, and the WN dopamine response shifted only partially toward its predictive cue. However, unpredicted WN provoked slower post-stimulus signal recovery than predicted WN. Despite differing signal qualities, dopamine responses to simultaneous presentation of rewarding and aversive stimuli were additive. Together, our findings demonstrate that instead of an APE, NAC dopamine primarily tracks prediction and duration of aversive events. eLife Sciences Publications, Ltd 2022-11-11 /pmc/articles/PMC9651945/ /pubmed/36366962 http://dx.doi.org/10.7554/eLife.82711 Text en © 2022, Goedhoop et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Goedhoop, Jessica N van den Boom, Bastijn JG Robke, Rhiannon Veen, Felice Fellinger, Lizz van Elzelingen, Wouter Arbab, Tara Willuhn, Ingo Nucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction error |
title | Nucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction error |
title_full | Nucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction error |
title_fullStr | Nucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction error |
title_full_unstemmed | Nucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction error |
title_short | Nucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction error |
title_sort | nucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction error |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651945/ https://www.ncbi.nlm.nih.gov/pubmed/36366962 http://dx.doi.org/10.7554/eLife.82711 |
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