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Nucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction error

There is active debate on the role of dopamine in processing aversive stimuli, where inferred roles range from no involvement at all, to signaling an aversive prediction error (APE). Here, we systematically investigate dopamine release in the nucleus accumbens core (NAC), which is closely linked to...

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Autores principales: Goedhoop, Jessica N, van den Boom, Bastijn JG, Robke, Rhiannon, Veen, Felice, Fellinger, Lizz, van Elzelingen, Wouter, Arbab, Tara, Willuhn, Ingo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651945/
https://www.ncbi.nlm.nih.gov/pubmed/36366962
http://dx.doi.org/10.7554/eLife.82711
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author Goedhoop, Jessica N
van den Boom, Bastijn JG
Robke, Rhiannon
Veen, Felice
Fellinger, Lizz
van Elzelingen, Wouter
Arbab, Tara
Willuhn, Ingo
author_facet Goedhoop, Jessica N
van den Boom, Bastijn JG
Robke, Rhiannon
Veen, Felice
Fellinger, Lizz
van Elzelingen, Wouter
Arbab, Tara
Willuhn, Ingo
author_sort Goedhoop, Jessica N
collection PubMed
description There is active debate on the role of dopamine in processing aversive stimuli, where inferred roles range from no involvement at all, to signaling an aversive prediction error (APE). Here, we systematically investigate dopamine release in the nucleus accumbens core (NAC), which is closely linked to reward prediction errors, in rats exposed to white noise (WN, a versatile, underutilized, aversive stimulus) and its predictive cues. Both induced a negative dopamine ramp, followed by slow signal recovery upon stimulus cessation. In contrast to reward conditioning, this dopamine signal was unaffected by WN value, context valence, or probabilistic contingencies, and the WN dopamine response shifted only partially toward its predictive cue. However, unpredicted WN provoked slower post-stimulus signal recovery than predicted WN. Despite differing signal qualities, dopamine responses to simultaneous presentation of rewarding and aversive stimuli were additive. Together, our findings demonstrate that instead of an APE, NAC dopamine primarily tracks prediction and duration of aversive events.
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spelling pubmed-96519452022-11-15 Nucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction error Goedhoop, Jessica N van den Boom, Bastijn JG Robke, Rhiannon Veen, Felice Fellinger, Lizz van Elzelingen, Wouter Arbab, Tara Willuhn, Ingo eLife Neuroscience There is active debate on the role of dopamine in processing aversive stimuli, where inferred roles range from no involvement at all, to signaling an aversive prediction error (APE). Here, we systematically investigate dopamine release in the nucleus accumbens core (NAC), which is closely linked to reward prediction errors, in rats exposed to white noise (WN, a versatile, underutilized, aversive stimulus) and its predictive cues. Both induced a negative dopamine ramp, followed by slow signal recovery upon stimulus cessation. In contrast to reward conditioning, this dopamine signal was unaffected by WN value, context valence, or probabilistic contingencies, and the WN dopamine response shifted only partially toward its predictive cue. However, unpredicted WN provoked slower post-stimulus signal recovery than predicted WN. Despite differing signal qualities, dopamine responses to simultaneous presentation of rewarding and aversive stimuli were additive. Together, our findings demonstrate that instead of an APE, NAC dopamine primarily tracks prediction and duration of aversive events. eLife Sciences Publications, Ltd 2022-11-11 /pmc/articles/PMC9651945/ /pubmed/36366962 http://dx.doi.org/10.7554/eLife.82711 Text en © 2022, Goedhoop et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Goedhoop, Jessica N
van den Boom, Bastijn JG
Robke, Rhiannon
Veen, Felice
Fellinger, Lizz
van Elzelingen, Wouter
Arbab, Tara
Willuhn, Ingo
Nucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction error
title Nucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction error
title_full Nucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction error
title_fullStr Nucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction error
title_full_unstemmed Nucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction error
title_short Nucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction error
title_sort nucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction error
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651945/
https://www.ncbi.nlm.nih.gov/pubmed/36366962
http://dx.doi.org/10.7554/eLife.82711
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