Comparative Study on the Measurement of Liver LICdw between Ferriscan and T2* Based LICdw Obtained by Different Software’s

OBJECTIVE: To explore the relationship between the liver iron concentration (LIC(F)) from FerriScan and T2* based LIC obtained by Circle Cardiovascular Imaging CVI42 (CVI42), CMRtools/Thalassemia Tools (CMRtools), and Excel spreadsheet (Excel). METHODS: Liver T2* values in 78 thalassemia patients were measured using CVI42, CMRtools, and Excel. Then the Garbowski formula was used to obtain LIC from T2*. Finally, the relationship of the LIC measured by the above three software and the LIC(F) were compared. RESULTS: There was no statistical difference between the T2* values measured by CVI42, CMRtools, and Excel (P>0.05), but there was a high degree of consistency between them (P<0.001), and there was a high linear positive correlation between them (P<0.001). There was no statistical difference between the LIC clinical grading results of CVI42, CMRtools, and Excel and LIC(F) grading results (P>0.05), and they were highly consistent (P<0.001). CONCLUSION: The liver T2* values measured by CVI42, CMRtools, and Excel are equivalent. The LIC measured by CVI42, CMRtools, and Excel is equivalent to the LIC(F).