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A Novel RANKL-Targeted Furoquinoline Alkaloid Ameliorates Bone Loss in Ovariectomized Osteoporosis through Inhibiting the NF-κB Signal Pathway and Reducing Reactive Oxygen Species

Dysregulation of osteoclast-osteoblast balance, resulting in abnormal bone remodeling, is responsible for postmenopausal osteoporosis (PMOP) or other secondary forms of osteoporosis. We demonstrated that dictamnine (DIC), a novel RANKL-targeted furoquinoline alkaloid, inhibits osteoclastogenesis by...

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Detalles Bibliográficos
Autores principales:	Wong, Puiian, Lv, Zheng, Li, Jinglan, Wei, Qiushi, Xu, LiangLiang, Fang, Bin, Luo, Yiwen, He, Mincong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652067/ https://www.ncbi.nlm.nih.gov/pubmed/36388169 http://dx.doi.org/10.1155/2022/5982014

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