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Effects of Descurainia sophia on Oxidative Stress Markers and Thirst Alleviation in Hemodialysis Patients: A Randomized Double-Blinded Placebo-Controlled Cross-Over Clinical Trial

BACKGROUND: Patients undergoing hemodialysis (HD) are regularly exposed to oxidative stress and inflammation and may suffer from thirst distress with no definitive treatment to address these complications. Descurainia sophia (DS) has been used to alleviate thirst in traditional Persian medicine. Thi...

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Autores principales: Asgharpour, Masoumeh, Enayati, Noora, Rezaei Sadrabadi, Mohammad, Mohamadi Afrakati, Mana, Khavandegar, Armin, Mardi, Parham, Alirezaei, Amirhesam, Taherinia, Ali, Bakhtiyari, Mahmood
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652079/
https://www.ncbi.nlm.nih.gov/pubmed/36387350
http://dx.doi.org/10.1155/2022/2001441
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author Asgharpour, Masoumeh
Enayati, Noora
Rezaei Sadrabadi, Mohammad
Mohamadi Afrakati, Mana
Khavandegar, Armin
Mardi, Parham
Alirezaei, Amirhesam
Taherinia, Ali
Bakhtiyari, Mahmood
author_facet Asgharpour, Masoumeh
Enayati, Noora
Rezaei Sadrabadi, Mohammad
Mohamadi Afrakati, Mana
Khavandegar, Armin
Mardi, Parham
Alirezaei, Amirhesam
Taherinia, Ali
Bakhtiyari, Mahmood
author_sort Asgharpour, Masoumeh
collection PubMed
description BACKGROUND: Patients undergoing hemodialysis (HD) are regularly exposed to oxidative stress and inflammation and may suffer from thirst distress with no definitive treatment to address these complications. Descurainia sophia (DS) has been used to alleviate thirst in traditional Persian medicine. This study aimed to assess the effectiveness of DS on oxidation factors and thirst score in HD patients. METHODS: This study was conducted on fifty-three HD patients referred to Tehran Shahid Modarres hospital. The patients were randomly divided into two groups: Group 1 received DS for six weeks, then underwent four weeks of washout period followed by six weeks of placebo treatment, while group 2 received placebo initially followed by treatment with DS. Biochemistry, malondialdehyde (MDA), and total antioxidant capacity (TAC) were measured in four phases: at the beginning, before washout, after washout, and at the end of the study. The patient's body weight was recorded at the start of each session to assess interdialytic weight gain. Thirst scores also were measured using a visual analog scale. RESULTS: A total of 53 patients, including 23 (43.4%) male and 30 (56.6%) female subjects, were included in the study. The results showed a reduction in thirst score (p=0.001), cholesterol levels (p=0.046), triglycerides (0.003), and MDA (p < 0.001) following the four-week administration of DS treatment in HD patients. The mean levels of TAC were increased (p < 0.001), and calcium, as well as Na+, remained unchanged (p > 0.05). Also, a significant decrease in the patient's weight was observed (p value <0.001). This effect persisted after shifting to a placebo. However, the two groups had no significant difference (p value = 0.539). CONCLUSION: DS powder-mixed syrup may benefit HD patients by facilitating free radical scavenging and alleviating thirst distress with minimal adverse effects. The seeds could therefore be utilized as a complementary therapy for hemodialysis patients.
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spelling pubmed-96520792022-11-15 Effects of Descurainia sophia on Oxidative Stress Markers and Thirst Alleviation in Hemodialysis Patients: A Randomized Double-Blinded Placebo-Controlled Cross-Over Clinical Trial Asgharpour, Masoumeh Enayati, Noora Rezaei Sadrabadi, Mohammad Mohamadi Afrakati, Mana Khavandegar, Armin Mardi, Parham Alirezaei, Amirhesam Taherinia, Ali Bakhtiyari, Mahmood Evid Based Complement Alternat Med Research Article BACKGROUND: Patients undergoing hemodialysis (HD) are regularly exposed to oxidative stress and inflammation and may suffer from thirst distress with no definitive treatment to address these complications. Descurainia sophia (DS) has been used to alleviate thirst in traditional Persian medicine. This study aimed to assess the effectiveness of DS on oxidation factors and thirst score in HD patients. METHODS: This study was conducted on fifty-three HD patients referred to Tehran Shahid Modarres hospital. The patients were randomly divided into two groups: Group 1 received DS for six weeks, then underwent four weeks of washout period followed by six weeks of placebo treatment, while group 2 received placebo initially followed by treatment with DS. Biochemistry, malondialdehyde (MDA), and total antioxidant capacity (TAC) were measured in four phases: at the beginning, before washout, after washout, and at the end of the study. The patient's body weight was recorded at the start of each session to assess interdialytic weight gain. Thirst scores also were measured using a visual analog scale. RESULTS: A total of 53 patients, including 23 (43.4%) male and 30 (56.6%) female subjects, were included in the study. The results showed a reduction in thirst score (p=0.001), cholesterol levels (p=0.046), triglycerides (0.003), and MDA (p < 0.001) following the four-week administration of DS treatment in HD patients. The mean levels of TAC were increased (p < 0.001), and calcium, as well as Na+, remained unchanged (p > 0.05). Also, a significant decrease in the patient's weight was observed (p value <0.001). This effect persisted after shifting to a placebo. However, the two groups had no significant difference (p value = 0.539). CONCLUSION: DS powder-mixed syrup may benefit HD patients by facilitating free radical scavenging and alleviating thirst distress with minimal adverse effects. The seeds could therefore be utilized as a complementary therapy for hemodialysis patients. Hindawi 2022-11-04 /pmc/articles/PMC9652079/ /pubmed/36387350 http://dx.doi.org/10.1155/2022/2001441 Text en Copyright © 2022 Masoumeh Asgharpour et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Asgharpour, Masoumeh
Enayati, Noora
Rezaei Sadrabadi, Mohammad
Mohamadi Afrakati, Mana
Khavandegar, Armin
Mardi, Parham
Alirezaei, Amirhesam
Taherinia, Ali
Bakhtiyari, Mahmood
Effects of Descurainia sophia on Oxidative Stress Markers and Thirst Alleviation in Hemodialysis Patients: A Randomized Double-Blinded Placebo-Controlled Cross-Over Clinical Trial
title Effects of Descurainia sophia on Oxidative Stress Markers and Thirst Alleviation in Hemodialysis Patients: A Randomized Double-Blinded Placebo-Controlled Cross-Over Clinical Trial
title_full Effects of Descurainia sophia on Oxidative Stress Markers and Thirst Alleviation in Hemodialysis Patients: A Randomized Double-Blinded Placebo-Controlled Cross-Over Clinical Trial
title_fullStr Effects of Descurainia sophia on Oxidative Stress Markers and Thirst Alleviation in Hemodialysis Patients: A Randomized Double-Blinded Placebo-Controlled Cross-Over Clinical Trial
title_full_unstemmed Effects of Descurainia sophia on Oxidative Stress Markers and Thirst Alleviation in Hemodialysis Patients: A Randomized Double-Blinded Placebo-Controlled Cross-Over Clinical Trial
title_short Effects of Descurainia sophia on Oxidative Stress Markers and Thirst Alleviation in Hemodialysis Patients: A Randomized Double-Blinded Placebo-Controlled Cross-Over Clinical Trial
title_sort effects of descurainia sophia on oxidative stress markers and thirst alleviation in hemodialysis patients: a randomized double-blinded placebo-controlled cross-over clinical trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652079/
https://www.ncbi.nlm.nih.gov/pubmed/36387350
http://dx.doi.org/10.1155/2022/2001441
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