pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation

The human transcriptome contains thousands of small open reading frames (sORFs) that encode microproteins whose functions remain largely unexplored. Here, we show that TINCR lncRNA encodes pTINCR, an evolutionary conserved ubiquitin-like protein (UBL) expressed in many epithelia and upregulated upon...

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Detalles Bibliográficos
Autores principales: Boix, Olga, Martinez, Marion, Vidal, Santiago, Giménez-Alejandre, Marta, Palenzuela, Lluís, Lorenzo-Sanz, Laura, Quevedo, Laura, Moscoso, Olivier, Ruiz-Orera, Jorge, Ximénez-Embún, Pilar, Ciriaco, Nikaoly, Nuciforo, Paolo, Stephan-Otto Attolini, Camille, Albà, M. Mar, Muñoz, Javier, Tian, Tian V., Varela, Ignacio, Vivancos, Ana, Ramón y Cajal, Santiago, Muñoz, Purificación, Rivas, Carmen, Abad, María
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652315/
https://www.ncbi.nlm.nih.gov/pubmed/36369429
http://dx.doi.org/10.1038/s41467-022-34529-6

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