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Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations
Helicobacter pylori lives in the human stomach and has a population structure resembling that of its host. However, H. pylori from Europe and the Middle East trace substantially more ancestry from modern African populations than the humans that carry them. Here, we use a collection of Afro-Eurasian...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652371/ https://www.ncbi.nlm.nih.gov/pubmed/36369175 http://dx.doi.org/10.1038/s41467-022-34475-3 |
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author | Thorpe, Harry A. Tourrette, Elise Yahara, Koji Vale, Filipa F. Liu, Siqi Oleastro, Mónica Alarcon, Teresa Perets, Tsachi-Tsadok Latifi-Navid, Saeid Yamaoka, Yoshio Martinez-Gonzalez, Beatriz Karayiannis, Ioannis Karamitros, Timokratis Sgouras, Dionyssios N. Elamin, Wael Pascoe, Ben Sheppard, Samuel K. Ronkainen, Jukka Aro, Pertti Engstrand, Lars Agreus, Lars Suerbaum, Sebastian Thorell, Kaisa Falush, Daniel |
author_facet | Thorpe, Harry A. Tourrette, Elise Yahara, Koji Vale, Filipa F. Liu, Siqi Oleastro, Mónica Alarcon, Teresa Perets, Tsachi-Tsadok Latifi-Navid, Saeid Yamaoka, Yoshio Martinez-Gonzalez, Beatriz Karayiannis, Ioannis Karamitros, Timokratis Sgouras, Dionyssios N. Elamin, Wael Pascoe, Ben Sheppard, Samuel K. Ronkainen, Jukka Aro, Pertti Engstrand, Lars Agreus, Lars Suerbaum, Sebastian Thorell, Kaisa Falush, Daniel |
author_sort | Thorpe, Harry A. |
collection | PubMed |
description | Helicobacter pylori lives in the human stomach and has a population structure resembling that of its host. However, H. pylori from Europe and the Middle East trace substantially more ancestry from modern African populations than the humans that carry them. Here, we use a collection of Afro-Eurasian H. pylori genomes to show that this African ancestry is due to at least three distinct admixture events. H. pylori from East Asia, which have undergone little admixture, have accumulated many more non-synonymous mutations than African strains. European and Middle Eastern bacteria have elevated African ancestry at the sites of these mutations, implying selection to remove them during admixture. Simulations show that population fitness can be restored after bottlenecks by migration and subsequent admixture of small numbers of bacteria from non-bottlenecked populations. We conclude that recent spread of African DNA has been driven by deleterious mutations accumulated during the original out-of-Africa bottleneck. |
format | Online Article Text |
id | pubmed-9652371 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-96523712022-11-15 Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations Thorpe, Harry A. Tourrette, Elise Yahara, Koji Vale, Filipa F. Liu, Siqi Oleastro, Mónica Alarcon, Teresa Perets, Tsachi-Tsadok Latifi-Navid, Saeid Yamaoka, Yoshio Martinez-Gonzalez, Beatriz Karayiannis, Ioannis Karamitros, Timokratis Sgouras, Dionyssios N. Elamin, Wael Pascoe, Ben Sheppard, Samuel K. Ronkainen, Jukka Aro, Pertti Engstrand, Lars Agreus, Lars Suerbaum, Sebastian Thorell, Kaisa Falush, Daniel Nat Commun Article Helicobacter pylori lives in the human stomach and has a population structure resembling that of its host. However, H. pylori from Europe and the Middle East trace substantially more ancestry from modern African populations than the humans that carry them. Here, we use a collection of Afro-Eurasian H. pylori genomes to show that this African ancestry is due to at least three distinct admixture events. H. pylori from East Asia, which have undergone little admixture, have accumulated many more non-synonymous mutations than African strains. European and Middle Eastern bacteria have elevated African ancestry at the sites of these mutations, implying selection to remove them during admixture. Simulations show that population fitness can be restored after bottlenecks by migration and subsequent admixture of small numbers of bacteria from non-bottlenecked populations. We conclude that recent spread of African DNA has been driven by deleterious mutations accumulated during the original out-of-Africa bottleneck. Nature Publishing Group UK 2022-11-11 /pmc/articles/PMC9652371/ /pubmed/36369175 http://dx.doi.org/10.1038/s41467-022-34475-3 Text en © The Author(s) 2022, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Thorpe, Harry A. Tourrette, Elise Yahara, Koji Vale, Filipa F. Liu, Siqi Oleastro, Mónica Alarcon, Teresa Perets, Tsachi-Tsadok Latifi-Navid, Saeid Yamaoka, Yoshio Martinez-Gonzalez, Beatriz Karayiannis, Ioannis Karamitros, Timokratis Sgouras, Dionyssios N. Elamin, Wael Pascoe, Ben Sheppard, Samuel K. Ronkainen, Jukka Aro, Pertti Engstrand, Lars Agreus, Lars Suerbaum, Sebastian Thorell, Kaisa Falush, Daniel Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations |
title | Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations |
title_full | Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations |
title_fullStr | Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations |
title_full_unstemmed | Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations |
title_short | Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations |
title_sort | repeated out-of-africa expansions of helicobacter pylori driven by replacement of deleterious mutations |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652371/ https://www.ncbi.nlm.nih.gov/pubmed/36369175 http://dx.doi.org/10.1038/s41467-022-34475-3 |
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