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The relationship between Alzheimer's‐related brain atrophy patterns and sleep macro‐architecture

INTRODUCTION: Sleep is increasingly recognized as a major risk factor for neurodegenerative disorders such as Alzheimer's disease (AD). METHODS: Using an magnetic resonance imaging (MRI)–based AD score based on clinical data from the Alzheimer's Disease Neuroimaging Initiative 1 (ADNI1) ca...

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Detalles Bibliográficos
Autores principales: Weihs, Antoine, Frenzel, Stefan, Garvert, Linda, Kühn, Luise, Wittfeld, Katharina, Ewert, Ralf, Fietze, Ingo, Penzel, Thomas, Stubbe, Beate, Szentkirályi, András, Wulms, Niklas, Völzke, Henry, Grabe, Hans J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652484/
https://www.ncbi.nlm.nih.gov/pubmed/36381559
http://dx.doi.org/10.1002/dad2.12371
Descripción
Sumario:INTRODUCTION: Sleep is increasingly recognized as a major risk factor for neurodegenerative disorders such as Alzheimer's disease (AD). METHODS: Using an magnetic resonance imaging (MRI)–based AD score based on clinical data from the Alzheimer's Disease Neuroimaging Initiative 1 (ADNI1) case‐control cohort, we investigated the associations between polysomnography‐based sleep macro‐architecture and AD‐related brain atrophy patterns in 712 pre‐symptomatic, healthy subjects from the population‐based Study of Health in Pomerania. RESULTS: We identified a robust inverse association between slow‐wave sleep and the AD marker (estimate: −0.019; 95% confidence interval: −0.03 to −0.0076; false discovery rate [FDR] = 0.0041), as well as with gray matter (GM) thicknesses in typical individual cortical AD‐signature regions. No effects were identified regarding rapid eye movement or non–rapid eye movement (NREM) stage 2 sleep, and NREM stage 1 was positively associated with GM thickness, mainly in the prefrontal cortical regions. DISCUSSION: There is a cross‐sectional relationship between AD‐related neurodegenerative patterns and the proportion of sleep spent in slow‐wave sleep.