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AAV2-Mediated Expression of HspB1 in RGCs Prevents Somal Damage and Axonal Transport Deficits in a Mouse Model of Ocular Hypertension

PURPOSE: Ocular hypertension is a significant risk factor for vision loss in glaucoma caused by the death of retinal ganglion cells (RGCs). We investigated whether small heat shock proteins (sHsps) expressed in RGCs protect those cells against ocular hypertension in mice. METHODS: AAV2 vectors encod...

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Detalles Bibliográficos
Autores principales:	Nam, Mi-Hyun, Nahomi, Rooban B., Pantcheva, Mina B., Dhillon, Armaan, Chiodo, Vince A., Smith, W. Clay, Nagaraj, Ram H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2022
Materias:	Glaucoma
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652726/ https://www.ncbi.nlm.nih.gov/pubmed/36355386 http://dx.doi.org/10.1167/tvst.11.11.8

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