Host genetic variability and determinants of severe COVID-19

Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak, convergent studies have provided evidence that host genetic background may contribute to the development of severe coronavirus disease (COVID-19). Here, we summarize how some genetic variations, such as in SARS-CoV-2 re...

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Autores principales: Brest, Patrick, Mograbi, Baharia, Gal, Jocelyn, Hofman, Paul, Milano, Gerard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2023
Materias:
Forum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652763/
https://www.ncbi.nlm.nih.gov/pubmed/36379742
http://dx.doi.org/10.1016/j.tig.2022.10.003
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author Brest, Patrick
Mograbi, Baharia
Gal, Jocelyn
Hofman, Paul
Milano, Gerard
author_facet Brest, Patrick
Mograbi, Baharia
Gal, Jocelyn
Hofman, Paul
Milano, Gerard
author_sort Brest, Patrick
collection PubMed
description Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak, convergent studies have provided evidence that host genetic background may contribute to the development of severe coronavirus disease (COVID-19). Here, we summarize how some genetic variations, such as in SARS-CoV-2 receptor angiotensin-converting enzyme 2 or interferon signaling pathway, may help to understand why some individuals can develop severe COVID-19.
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spelling pubmed-96527632022-11-14 Host genetic variability and determinants of severe COVID-19 Brest, Patrick Mograbi, Baharia Gal, Jocelyn Hofman, Paul Milano, Gerard Trends Genet Forum Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak, convergent studies have provided evidence that host genetic background may contribute to the development of severe coronavirus disease (COVID-19). Here, we summarize how some genetic variations, such as in SARS-CoV-2 receptor angiotensin-converting enzyme 2 or interferon signaling pathway, may help to understand why some individuals can develop severe COVID-19. Elsevier Ltd. 2023-03 2022-11-12 /pmc/articles/PMC9652763/ /pubmed/36379742 http://dx.doi.org/10.1016/j.tig.2022.10.003 Text en © 2022 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Forum
Brest, Patrick
Mograbi, Baharia
Gal, Jocelyn
Hofman, Paul
Milano, Gerard
Host genetic variability and determinants of severe COVID-19
title Host genetic variability and determinants of severe COVID-19
title_full Host genetic variability and determinants of severe COVID-19
title_fullStr Host genetic variability and determinants of severe COVID-19
title_full_unstemmed Host genetic variability and determinants of severe COVID-19
title_short Host genetic variability and determinants of severe COVID-19
title_sort host genetic variability and determinants of severe covid-19
topic Forum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652763/
https://www.ncbi.nlm.nih.gov/pubmed/36379742
http://dx.doi.org/10.1016/j.tig.2022.10.003
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