Ca(2+) dysregulation in cardiac stromal cells sustains fibro-adipose remodeling in Arrhythmogenic Cardiomyopathy and can be modulated by flecainide

BACKGROUND: Cardiac mesenchymal stromal cells (C-MSC) were recently shown to differentiate into adipocytes and myofibroblasts to promote the aberrant remodeling of cardiac tissue that characterizes arrhythmogenic cardiomyopathy (ACM). A calcium (Ca(2+)) signaling dysfunction, mainly demonstrated in...

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Detalles Bibliográficos
Autores principales: Maione, Angela S., Faris, Pawan, Iengo, Lara, Catto, Valentina, Bisonni, Luca, Lodola, Francesco, Negri, Sharon, Casella, Michela, Guarino, Anna, Polvani, Gianluca, Cerrone, Marina, Tondo, Claudio, Pompilio, Giulio, Sommariva, Elena, Moccia, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652790/
https://www.ncbi.nlm.nih.gov/pubmed/36371290
http://dx.doi.org/10.1186/s12967-022-03742-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652790/
https://www.ncbi.nlm.nih.gov/pubmed/36371290
http://dx.doi.org/10.1186/s12967-022-03742-8

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