Roles of N(6)-methyladenosine (m(6)A) modifications in gynecologic cancers: mechanisms and therapeutic targeting

Uterine and ovarian cancers are the most common gynecologic cancers. N(6−)methyladenosine (m(6)A), an important internal RNA modification in higher eukaryotes, has recently become a hot topic in epigenetic studies. Numerous studies have revealed that the m(6)A-related regulatory factors regulate the...

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Autores principales: Chen, Jiahua, Guo, Bao, Liu, Xiaojing, Zhang, Jing, Zhang, Junhui, Fang, Yuan, Zhu, Suding, Wei, Bing, Cao, Yunxia, Zhan, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652818/
https://www.ncbi.nlm.nih.gov/pubmed/36371254
http://dx.doi.org/10.1186/s40164-022-00357-z
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author Chen, Jiahua
Guo, Bao
Liu, Xiaojing
Zhang, Jing
Zhang, Junhui
Fang, Yuan
Zhu, Suding
Wei, Bing
Cao, Yunxia
Zhan, Lei
author_facet Chen, Jiahua
Guo, Bao
Liu, Xiaojing
Zhang, Jing
Zhang, Junhui
Fang, Yuan
Zhu, Suding
Wei, Bing
Cao, Yunxia
Zhan, Lei
author_sort Chen, Jiahua
collection PubMed
description Uterine and ovarian cancers are the most common gynecologic cancers. N(6−)methyladenosine (m(6)A), an important internal RNA modification in higher eukaryotes, has recently become a hot topic in epigenetic studies. Numerous studies have revealed that the m(6)A-related regulatory factors regulate the occurrence and metastasis of tumors and drug resistance through various mechanisms. The m(6)A-related regulatory factors can also be used as therapeutic targets and biomarkers for the early diagnosis of cancers, including gynecologic cancers. This review discusses the role of m(6)A in gynecologic cancers and summarizes the recent advancements in m(6)A modification in gynecologic cancers to improve the understanding of the occurrence, diagnosis, treatment, and prognosis of gynecologic cancers.
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spelling pubmed-96528182022-11-15 Roles of N(6)-methyladenosine (m(6)A) modifications in gynecologic cancers: mechanisms and therapeutic targeting Chen, Jiahua Guo, Bao Liu, Xiaojing Zhang, Jing Zhang, Junhui Fang, Yuan Zhu, Suding Wei, Bing Cao, Yunxia Zhan, Lei Exp Hematol Oncol Review Uterine and ovarian cancers are the most common gynecologic cancers. N(6−)methyladenosine (m(6)A), an important internal RNA modification in higher eukaryotes, has recently become a hot topic in epigenetic studies. Numerous studies have revealed that the m(6)A-related regulatory factors regulate the occurrence and metastasis of tumors and drug resistance through various mechanisms. The m(6)A-related regulatory factors can also be used as therapeutic targets and biomarkers for the early diagnosis of cancers, including gynecologic cancers. This review discusses the role of m(6)A in gynecologic cancers and summarizes the recent advancements in m(6)A modification in gynecologic cancers to improve the understanding of the occurrence, diagnosis, treatment, and prognosis of gynecologic cancers. BioMed Central 2022-11-12 /pmc/articles/PMC9652818/ /pubmed/36371254 http://dx.doi.org/10.1186/s40164-022-00357-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Chen, Jiahua
Guo, Bao
Liu, Xiaojing
Zhang, Jing
Zhang, Junhui
Fang, Yuan
Zhu, Suding
Wei, Bing
Cao, Yunxia
Zhan, Lei
Roles of N(6)-methyladenosine (m(6)A) modifications in gynecologic cancers: mechanisms and therapeutic targeting
title Roles of N(6)-methyladenosine (m(6)A) modifications in gynecologic cancers: mechanisms and therapeutic targeting
title_full Roles of N(6)-methyladenosine (m(6)A) modifications in gynecologic cancers: mechanisms and therapeutic targeting
title_fullStr Roles of N(6)-methyladenosine (m(6)A) modifications in gynecologic cancers: mechanisms and therapeutic targeting
title_full_unstemmed Roles of N(6)-methyladenosine (m(6)A) modifications in gynecologic cancers: mechanisms and therapeutic targeting
title_short Roles of N(6)-methyladenosine (m(6)A) modifications in gynecologic cancers: mechanisms and therapeutic targeting
title_sort roles of n(6)-methyladenosine (m(6)a) modifications in gynecologic cancers: mechanisms and therapeutic targeting
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652818/
https://www.ncbi.nlm.nih.gov/pubmed/36371254
http://dx.doi.org/10.1186/s40164-022-00357-z
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