Retained introns in long RNA-seq reads are not reliably detected in sample-matched short reads

BACKGROUND: There is growing interest in retained introns in a variety of disease contexts including cancer and aging. Many software tools have been developed to detect retained introns from short RNA-seq reads, but reliable detection is complicated by overlapping genes and transcripts as well as th...

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Detalles Bibliográficos
Autores principales: David, Julianne K., Maden, Sean K., Wood, Mary A., Thompson, Reid F., Nellore, Abhinav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652823/
https://www.ncbi.nlm.nih.gov/pubmed/36369064
http://dx.doi.org/10.1186/s13059-022-02789-6

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