Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders

Alpha-synuclein (aSyn) is a pre-synaptic monomeric protein that can form aggregates in neurons in Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD) and dementia with Lewy bodies (DLB), and in oligodendrocytes in multiple system atrophy (MSA). Although aSyn in astrocytes has previousl...

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Detalles Bibliográficos
Autores principales: Altay, Melek Firat, Liu, Alan King Lun, Holton, Janice L., Parkkinen, Laura, Lashuel, Hilal A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652889/
https://www.ncbi.nlm.nih.gov/pubmed/36371251
http://dx.doi.org/10.1186/s40478-022-01468-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652889/
https://www.ncbi.nlm.nih.gov/pubmed/36371251
http://dx.doi.org/10.1186/s40478-022-01468-8

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