SWI/SNF complex gene variations are associated with a higher tumor mutational burden and a better response to immune checkpoint inhibitor treatment: a pan-cancer analysis of next-generation sequencing data corresponding to 4591 cases

BACKGROUND: Genes related to the SWItch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex are frequently mutated across cancers. SWI/SNF-mutant tumors are vulnerable to synthetic lethal inhibitors. However, the landscape of SWI/SNF mutations and their associations with tumor mutational b...

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Detalles Bibliográficos
Autores principales: Li, Yue, Yang, Xinhua, Zhu, Weijie, Xu, Yuxia, Ma, Jiangjun, He, Caiyun, Wang, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652899/
https://www.ncbi.nlm.nih.gov/pubmed/36371186
http://dx.doi.org/10.1186/s12935-022-02757-x

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