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Association of Underlying Comorbidities and Sites of tuberculosis: an analysis using surveillance data

BACKGROUND: Tuberculosis (TB) is a highly heterogeneous disease that can affect any organ. Extrapulmonary TB (EPTB) is more difficult to diagnose due to various clinical presentations. Depending on the characteristics of the patient, the involved site of TB may vary. However, data on clinical charac...

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Autores principales: Jeong, Yun-Jeong, Kang, Ji Young, Kim, Hyung Woo, Min, Jinsoo, Ko, Yousang, Oh, Jee Youn, Kang, Hyeon Hui, Lim, Sung Chul, Hwang, Hun-Gyu, Shin, Kyeong-Cheol, Lee, Heung Bum, Kim, Ju Sang, Park, Jae Seuk, Lee, Sung Soon, Koo, Hyeon-Kyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652946/
https://www.ncbi.nlm.nih.gov/pubmed/36371212
http://dx.doi.org/10.1186/s12890-022-02224-3
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author Jeong, Yun-Jeong
Kang, Ji Young
Kim, Hyung Woo
Min, Jinsoo
Ko, Yousang
Oh, Jee Youn
Kang, Hyeon Hui
Lim, Sung Chul
Hwang, Hun-Gyu
Shin, Kyeong-Cheol
Lee, Heung Bum
Kim, Ju Sang
Park, Jae Seuk
Lee, Sung Soon
Koo, Hyeon-Kyoung
author_facet Jeong, Yun-Jeong
Kang, Ji Young
Kim, Hyung Woo
Min, Jinsoo
Ko, Yousang
Oh, Jee Youn
Kang, Hyeon Hui
Lim, Sung Chul
Hwang, Hun-Gyu
Shin, Kyeong-Cheol
Lee, Heung Bum
Kim, Ju Sang
Park, Jae Seuk
Lee, Sung Soon
Koo, Hyeon-Kyoung
author_sort Jeong, Yun-Jeong
collection PubMed
description BACKGROUND: Tuberculosis (TB) is a highly heterogeneous disease that can affect any organ. Extrapulmonary TB (EPTB) is more difficult to diagnose due to various clinical presentations. Depending on the characteristics of the patient, the involved site of TB may vary. However, data on clinical characteristics of EPTB are inconsistent and insufficient. This study aimed to identify the characteristics of patients with pulmonary TB (PTB) and EPTB and describe characteristic differences for each involved site. METHODS: We systemically collected data of TB patients included in the national surveillance system in South Korea from July 2018 to June 2019 and compared the characteristics of patients with EPTB with that of PTB. RESULTS: A total of 7674 patients with a mean age of 60.9 years were included. Among them, 6038 (78.7%) patients were diagnosed with PTB and 1636 (21.3%) with EPTB. In PTB group, the mean age (61.7 ± 18.7 vs. 57.8 ± 19.9) and proportion of male sex (63.3% vs. 50.1%) were higher, but the body mass index was lower (21.2 ± 3.4 vs. 22.7 ± 3.5) than that of the EPTB group. Prevalence of diabetes (20.5% vs. 16.9%) and chronic lung disease (5.1% vs. 2.9%) were higher in PTB group, meanwhile, those of chronic kidney disease (CKD) (2.7% vs. 5.4%) and long-term steroid use (0.4% vs. 1.0%) were higher in EPTB group. Abdominal TB was more prevalent in patients with chronic liver disease (odds ratio [OR]: 2.69, 95% CI: 1.52–4.74), and urogenital TB was more prevalent in patients with CKD (OR: 2.75, 95% CI: 1.08–6.99). CONCLUSIONS: We found that underlying comorbidities were closely associated with the location of TB development, and therefore, the possibility of EPTB should be carefully evaluated while monitoring for underlying disease in TB-endemic areas. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12890-022-02224-3.
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spelling pubmed-96529462022-11-15 Association of Underlying Comorbidities and Sites of tuberculosis: an analysis using surveillance data Jeong, Yun-Jeong Kang, Ji Young Kim, Hyung Woo Min, Jinsoo Ko, Yousang Oh, Jee Youn Kang, Hyeon Hui Lim, Sung Chul Hwang, Hun-Gyu Shin, Kyeong-Cheol Lee, Heung Bum Kim, Ju Sang Park, Jae Seuk Lee, Sung Soon Koo, Hyeon-Kyoung BMC Pulm Med Research BACKGROUND: Tuberculosis (TB) is a highly heterogeneous disease that can affect any organ. Extrapulmonary TB (EPTB) is more difficult to diagnose due to various clinical presentations. Depending on the characteristics of the patient, the involved site of TB may vary. However, data on clinical characteristics of EPTB are inconsistent and insufficient. This study aimed to identify the characteristics of patients with pulmonary TB (PTB) and EPTB and describe characteristic differences for each involved site. METHODS: We systemically collected data of TB patients included in the national surveillance system in South Korea from July 2018 to June 2019 and compared the characteristics of patients with EPTB with that of PTB. RESULTS: A total of 7674 patients with a mean age of 60.9 years were included. Among them, 6038 (78.7%) patients were diagnosed with PTB and 1636 (21.3%) with EPTB. In PTB group, the mean age (61.7 ± 18.7 vs. 57.8 ± 19.9) and proportion of male sex (63.3% vs. 50.1%) were higher, but the body mass index was lower (21.2 ± 3.4 vs. 22.7 ± 3.5) than that of the EPTB group. Prevalence of diabetes (20.5% vs. 16.9%) and chronic lung disease (5.1% vs. 2.9%) were higher in PTB group, meanwhile, those of chronic kidney disease (CKD) (2.7% vs. 5.4%) and long-term steroid use (0.4% vs. 1.0%) were higher in EPTB group. Abdominal TB was more prevalent in patients with chronic liver disease (odds ratio [OR]: 2.69, 95% CI: 1.52–4.74), and urogenital TB was more prevalent in patients with CKD (OR: 2.75, 95% CI: 1.08–6.99). CONCLUSIONS: We found that underlying comorbidities were closely associated with the location of TB development, and therefore, the possibility of EPTB should be carefully evaluated while monitoring for underlying disease in TB-endemic areas. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12890-022-02224-3. BioMed Central 2022-11-12 /pmc/articles/PMC9652946/ /pubmed/36371212 http://dx.doi.org/10.1186/s12890-022-02224-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Jeong, Yun-Jeong
Kang, Ji Young
Kim, Hyung Woo
Min, Jinsoo
Ko, Yousang
Oh, Jee Youn
Kang, Hyeon Hui
Lim, Sung Chul
Hwang, Hun-Gyu
Shin, Kyeong-Cheol
Lee, Heung Bum
Kim, Ju Sang
Park, Jae Seuk
Lee, Sung Soon
Koo, Hyeon-Kyoung
Association of Underlying Comorbidities and Sites of tuberculosis: an analysis using surveillance data
title Association of Underlying Comorbidities and Sites of tuberculosis: an analysis using surveillance data
title_full Association of Underlying Comorbidities and Sites of tuberculosis: an analysis using surveillance data
title_fullStr Association of Underlying Comorbidities and Sites of tuberculosis: an analysis using surveillance data
title_full_unstemmed Association of Underlying Comorbidities and Sites of tuberculosis: an analysis using surveillance data
title_short Association of Underlying Comorbidities and Sites of tuberculosis: an analysis using surveillance data
title_sort association of underlying comorbidities and sites of tuberculosis: an analysis using surveillance data
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652946/
https://www.ncbi.nlm.nih.gov/pubmed/36371212
http://dx.doi.org/10.1186/s12890-022-02224-3
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