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Development of a novel BRCAness score that predicts response to PARP inhibitors

BACKGROUND: BRCAness is a characteristic feature of homologous recombination deficiency (HRD) mimicking BRCA gene mutation in breast cancer. We hypothesized that a measure to quantify BRCAness that causes synthetic lethality in BRCA mutated tumors will identify responders to PARP inhibitors. METHODS...

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Detalles Bibliográficos
Autores principales:	Oshi, Masanori, Gandhi, Shipra, Wu, Rongrong, Asaoka, Mariko, Yan, Li, Yamada, Akimitsu, Yamamoto, Shinya, Narui, Kazutaka, Chishima, Takashi, Ishikawa, Takashi, Endo, Itaru, Takabe, Kazuaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652967/ https://www.ncbi.nlm.nih.gov/pubmed/36371386 http://dx.doi.org/10.1186/s40364-022-00427-8

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