mTORC1-c-Myc pathway rewires methionine metabolism for HCC progression through suppressing SIRT4 mediated ADP ribosylation of MAT2A

BACKGROUND: Exploiting cancer metabolism during nutrient availability holds immense potential for the clinical and therapeutic benefits of hepatocellular carcinoma (HCC) patients. Dietary methionine is a metabolic dependence of cancer development, but how the signal transduction integrates methionin...

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Detalles Bibliográficos
Autores principales: Zhao, Liang, Su, Huizhao, Liu, Xiaomeng, Wang, Hongquan, Feng, Yukuan, Wang, Yan, Chen, Haiqiang, Dai, Luo, Lai, Shihui, Xu, Siqi, Li, Chong, Hao, Jihui, Tang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652997/
https://www.ncbi.nlm.nih.gov/pubmed/36371321
http://dx.doi.org/10.1186/s13578-022-00919-y

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