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Acute Cholelithiasis With Acute Pancreatic Calcifications: A Unique Presentation of Sickle Cell Crisis

Sickle cell disease is one of the most prevalent hemoglobinopathies around the world. Sickle cell anemia manifests due to a genetic alteration caused by substituting a single nucleotide in place of another nucleotide in the beta-globin gene. This mutation causes rigidity and sickling of the erythroc...

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Detalles Bibliográficos
Autores principales: Popat, Nidhi, Kumar, Sunil, Unadkat, Bhavik S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653209/
https://www.ncbi.nlm.nih.gov/pubmed/36381715
http://dx.doi.org/10.7759/cureus.30272
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author Popat, Nidhi
Kumar, Sunil
Unadkat, Bhavik S
author_facet Popat, Nidhi
Kumar, Sunil
Unadkat, Bhavik S
author_sort Popat, Nidhi
collection PubMed
description Sickle cell disease is one of the most prevalent hemoglobinopathies around the world. Sickle cell anemia manifests due to a genetic alteration caused by substituting a single nucleotide in place of another nucleotide in the beta-globin gene. This mutation causes rigidity and sickling of the erythrocytes when the oxygen saturation falls in conditions like infection, dehydration, stress, etc. The distorted erythrocytes cause vaso-occlusion, tissue ischemia, and infarction. Cholelithiasis is known to be a frequent complication in cases of sickle cell anemia. It occurs because of chronic hemolysis. In sickle cell patients, calcific pancreatitis is an infrequent complication of vaso-occlusive crisis. It appears in connection with cholelithiasis in most patients. This case report highlights a rare presentation of sickle cell crisis complicated with multiple pigmented gall bladder calculi and pancreatic calcifications.
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spelling pubmed-96532092022-11-14 Acute Cholelithiasis With Acute Pancreatic Calcifications: A Unique Presentation of Sickle Cell Crisis Popat, Nidhi Kumar, Sunil Unadkat, Bhavik S Cureus Internal Medicine Sickle cell disease is one of the most prevalent hemoglobinopathies around the world. Sickle cell anemia manifests due to a genetic alteration caused by substituting a single nucleotide in place of another nucleotide in the beta-globin gene. This mutation causes rigidity and sickling of the erythrocytes when the oxygen saturation falls in conditions like infection, dehydration, stress, etc. The distorted erythrocytes cause vaso-occlusion, tissue ischemia, and infarction. Cholelithiasis is known to be a frequent complication in cases of sickle cell anemia. It occurs because of chronic hemolysis. In sickle cell patients, calcific pancreatitis is an infrequent complication of vaso-occlusive crisis. It appears in connection with cholelithiasis in most patients. This case report highlights a rare presentation of sickle cell crisis complicated with multiple pigmented gall bladder calculi and pancreatic calcifications. Cureus 2022-10-13 /pmc/articles/PMC9653209/ /pubmed/36381715 http://dx.doi.org/10.7759/cureus.30272 Text en Copyright © 2022, Popat et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Popat, Nidhi
Kumar, Sunil
Unadkat, Bhavik S
Acute Cholelithiasis With Acute Pancreatic Calcifications: A Unique Presentation of Sickle Cell Crisis
title Acute Cholelithiasis With Acute Pancreatic Calcifications: A Unique Presentation of Sickle Cell Crisis
title_full Acute Cholelithiasis With Acute Pancreatic Calcifications: A Unique Presentation of Sickle Cell Crisis
title_fullStr Acute Cholelithiasis With Acute Pancreatic Calcifications: A Unique Presentation of Sickle Cell Crisis
title_full_unstemmed Acute Cholelithiasis With Acute Pancreatic Calcifications: A Unique Presentation of Sickle Cell Crisis
title_short Acute Cholelithiasis With Acute Pancreatic Calcifications: A Unique Presentation of Sickle Cell Crisis
title_sort acute cholelithiasis with acute pancreatic calcifications: a unique presentation of sickle cell crisis
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653209/
https://www.ncbi.nlm.nih.gov/pubmed/36381715
http://dx.doi.org/10.7759/cureus.30272
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