NDUFS3 knockout cancer cells and molecular docking reveal specificity and mode of action of anti-cancer respiratory complex I inhibitors

Inhibition of respiratory complex I (CI) is becoming a promising anti-cancer strategy, encouraging the design and the use of inhibitors, whose mechanism of action, efficacy and specificity remain elusive. As CI is a central player of cellular bioenergetics, a finely tuned dosing of targeting drugs i...

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Detalles Bibliográficos
Autores principales: Kurelac, Ivana, Cavina, Beatrice, Sollazzo, Manuela, Miglietta, Stefano, Fornasa, Agnese, De Luise, Monica, Iorio, Maria, Lama, Eleonora, Traversa, Daniele, Nasiri, Hamid Razi, Ghelli, Anna, Musiani, Francesco, Porcelli, Anna Maria, Iommarini, Luisa, Gasparre, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653258/
https://www.ncbi.nlm.nih.gov/pubmed/36349549
http://dx.doi.org/10.1098/rsob.220198

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