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The role of the default mode network in longitudinal functional brain reorganization of brain gliomas
The study of patients after glioma resection offers a unique opportunity to investigate brain reorganization. It is currently unknown how the whole-brain connectomic profile evolves longitudinally after surgical resection of a glioma and how this may be associated with tumor characteristics and cogn...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653323/ https://www.ncbi.nlm.nih.gov/pubmed/35460446 http://dx.doi.org/10.1007/s00429-022-02490-1 |
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author | Saviola, Francesca Zigiotto, Luca Novello, Lisa Zacà, Domenico Annicchiarico, Luciano Corsini, Francesco Rozzanigo, Umberto Papagno, Costanza Jovicich, Jorge Sarubbo, Silvio |
author_facet | Saviola, Francesca Zigiotto, Luca Novello, Lisa Zacà, Domenico Annicchiarico, Luciano Corsini, Francesco Rozzanigo, Umberto Papagno, Costanza Jovicich, Jorge Sarubbo, Silvio |
author_sort | Saviola, Francesca |
collection | PubMed |
description | The study of patients after glioma resection offers a unique opportunity to investigate brain reorganization. It is currently unknown how the whole-brain connectomic profile evolves longitudinally after surgical resection of a glioma and how this may be associated with tumor characteristics and cognitive outcome. In this longitudinal study, we investigate the impact of tumor lateralization and grade on functional connectivity (FC) in highly connected networks, or hubs, and cognitive performance. Twenty-eight patients (17 high-grade, 11 low-grade gliomas) underwent longitudinal pre/post-surgery resting-state fMRI scans and neuropsychological assessments (73 total measures). FC matrices were constructed considering as functional hubs the default mode (DMN) and fronto-parietal networks. No-hubs included primary sensory functional networks and any other no-hubs nodes. Both tumor hemisphere and grade affected brain reorganization post-resection. In right-hemisphere tumor patients, regardless of grade and relative to left-hemisphere gliomas, FC increased longitudinally after the intervention, both in terms of FC within hubs (p(hubs) = 0.0004) and FC between hubs and no-hubs (p(hubs-no-hubs) = 0.005). Regardless of tumor side, only lower-grade gliomas showed longitudinal FC increases relative to high-grade tumors within a precise hub network, the DMN. The neurocognitive profile was longitudinally associated with spatial features of the connectome, mainly within the DMN. We provide evidence that clinical glioma features, such as lateralization and grade, affect post-surgical longitudinal functional reorganization and cognitive recovery. The data suggest a possible role of the DMN in supporting cognition, providing useful information for prognostic prediction and surgical planning. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00429-022-02490-1. |
format | Online Article Text |
id | pubmed-9653323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-96533232022-11-15 The role of the default mode network in longitudinal functional brain reorganization of brain gliomas Saviola, Francesca Zigiotto, Luca Novello, Lisa Zacà, Domenico Annicchiarico, Luciano Corsini, Francesco Rozzanigo, Umberto Papagno, Costanza Jovicich, Jorge Sarubbo, Silvio Brain Struct Funct Original Article The study of patients after glioma resection offers a unique opportunity to investigate brain reorganization. It is currently unknown how the whole-brain connectomic profile evolves longitudinally after surgical resection of a glioma and how this may be associated with tumor characteristics and cognitive outcome. In this longitudinal study, we investigate the impact of tumor lateralization and grade on functional connectivity (FC) in highly connected networks, or hubs, and cognitive performance. Twenty-eight patients (17 high-grade, 11 low-grade gliomas) underwent longitudinal pre/post-surgery resting-state fMRI scans and neuropsychological assessments (73 total measures). FC matrices were constructed considering as functional hubs the default mode (DMN) and fronto-parietal networks. No-hubs included primary sensory functional networks and any other no-hubs nodes. Both tumor hemisphere and grade affected brain reorganization post-resection. In right-hemisphere tumor patients, regardless of grade and relative to left-hemisphere gliomas, FC increased longitudinally after the intervention, both in terms of FC within hubs (p(hubs) = 0.0004) and FC between hubs and no-hubs (p(hubs-no-hubs) = 0.005). Regardless of tumor side, only lower-grade gliomas showed longitudinal FC increases relative to high-grade tumors within a precise hub network, the DMN. The neurocognitive profile was longitudinally associated with spatial features of the connectome, mainly within the DMN. We provide evidence that clinical glioma features, such as lateralization and grade, affect post-surgical longitudinal functional reorganization and cognitive recovery. The data suggest a possible role of the DMN in supporting cognition, providing useful information for prognostic prediction and surgical planning. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00429-022-02490-1. Springer Berlin Heidelberg 2022-04-23 2022 /pmc/articles/PMC9653323/ /pubmed/35460446 http://dx.doi.org/10.1007/s00429-022-02490-1 Text en © The Author(s) 2022, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Saviola, Francesca Zigiotto, Luca Novello, Lisa Zacà, Domenico Annicchiarico, Luciano Corsini, Francesco Rozzanigo, Umberto Papagno, Costanza Jovicich, Jorge Sarubbo, Silvio The role of the default mode network in longitudinal functional brain reorganization of brain gliomas |
title | The role of the default mode network in longitudinal functional brain reorganization of brain gliomas |
title_full | The role of the default mode network in longitudinal functional brain reorganization of brain gliomas |
title_fullStr | The role of the default mode network in longitudinal functional brain reorganization of brain gliomas |
title_full_unstemmed | The role of the default mode network in longitudinal functional brain reorganization of brain gliomas |
title_short | The role of the default mode network in longitudinal functional brain reorganization of brain gliomas |
title_sort | role of the default mode network in longitudinal functional brain reorganization of brain gliomas |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653323/ https://www.ncbi.nlm.nih.gov/pubmed/35460446 http://dx.doi.org/10.1007/s00429-022-02490-1 |
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