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Immune response associated with ischemia and reperfusion injury during organ transplantation
BACKGROUND: Ischemia and reperfusion injury (IRI) is an ineluctable immune-related pathophysiological process during organ transplantation, which not only causes a shortage of donor organs, but also has long-term and short-term negative consequences on patients. Severe IRI-induced cell death leads t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653341/ https://www.ncbi.nlm.nih.gov/pubmed/36282292 http://dx.doi.org/10.1007/s00011-022-01651-6 |
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author | Tang, Qiao Dong, Chong Sun, Qian |
author_facet | Tang, Qiao Dong, Chong Sun, Qian |
author_sort | Tang, Qiao |
collection | PubMed |
description | BACKGROUND: Ischemia and reperfusion injury (IRI) is an ineluctable immune-related pathophysiological process during organ transplantation, which not only causes a shortage of donor organs, but also has long-term and short-term negative consequences on patients. Severe IRI-induced cell death leads to the release of endogenous substances, which bind specifically to receptors on immune cells to initiate an immune response. Although innate and adaptive immunity have been discovered to play essential roles in IRI in the context of organ transplantation, the pathway and precise involvement of the immune response at various stages has not yet to be elucidated. METHODS: We combined “IRI” and “organ transplantation” with keywords, respectively such as immune cells, danger signal molecules, macrophages, neutrophils, natural killer cells, complement cascade, T cells or B cells in PubMed and the Web of Science to search for relevant literatures. CONCLUSION: Comprehension of the immune mechanisms involved in organ transplantation is promising for the treatment of IRI, this review summarizes the similarities and differences in both innate and adaptive immunity and advancements in the immune response associated with IRI during diverse organ transplantation. |
format | Online Article Text |
id | pubmed-9653341 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-96533412022-11-15 Immune response associated with ischemia and reperfusion injury during organ transplantation Tang, Qiao Dong, Chong Sun, Qian Inflamm Res Review BACKGROUND: Ischemia and reperfusion injury (IRI) is an ineluctable immune-related pathophysiological process during organ transplantation, which not only causes a shortage of donor organs, but also has long-term and short-term negative consequences on patients. Severe IRI-induced cell death leads to the release of endogenous substances, which bind specifically to receptors on immune cells to initiate an immune response. Although innate and adaptive immunity have been discovered to play essential roles in IRI in the context of organ transplantation, the pathway and precise involvement of the immune response at various stages has not yet to be elucidated. METHODS: We combined “IRI” and “organ transplantation” with keywords, respectively such as immune cells, danger signal molecules, macrophages, neutrophils, natural killer cells, complement cascade, T cells or B cells in PubMed and the Web of Science to search for relevant literatures. CONCLUSION: Comprehension of the immune mechanisms involved in organ transplantation is promising for the treatment of IRI, this review summarizes the similarities and differences in both innate and adaptive immunity and advancements in the immune response associated with IRI during diverse organ transplantation. Springer International Publishing 2022-10-25 2022 /pmc/articles/PMC9653341/ /pubmed/36282292 http://dx.doi.org/10.1007/s00011-022-01651-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Tang, Qiao Dong, Chong Sun, Qian Immune response associated with ischemia and reperfusion injury during organ transplantation |
title | Immune response associated with ischemia and reperfusion injury during organ transplantation |
title_full | Immune response associated with ischemia and reperfusion injury during organ transplantation |
title_fullStr | Immune response associated with ischemia and reperfusion injury during organ transplantation |
title_full_unstemmed | Immune response associated with ischemia and reperfusion injury during organ transplantation |
title_short | Immune response associated with ischemia and reperfusion injury during organ transplantation |
title_sort | immune response associated with ischemia and reperfusion injury during organ transplantation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653341/ https://www.ncbi.nlm.nih.gov/pubmed/36282292 http://dx.doi.org/10.1007/s00011-022-01651-6 |
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