DOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomers

Parkinson’s disease is a progressive neurodegenerative disorder characterized by the preferential loss of tyrosine hydroxylase (TH)-expressing dopaminergic neurons in the substantia nigra. Although the abnormal accumulation and aggregation of α-synuclein have been implicated in the pathogenesis of P...

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Detalles Bibliográficos
Autores principales: Jin, Mingyue, Matsumoto, Sakiko, Ayaki, Takashi, Yamakado, Hodaka, Taguchi, Tomoyuki, Togawa, Natsuko, Konno, Ayumu, Hirai, Hirokazu, Nakajima, Hiroshi, Komai, Shoji, Ishida, Ryuichi, Chiba, Syuhei, Takahashi, Ryosuke, Takao, Toshifumi, Hirotsune, Shinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653393/
https://www.ncbi.nlm.nih.gov/pubmed/36371400
http://dx.doi.org/10.1038/s41467-022-34555-4

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