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TLR3 forms a highly organized cluster when bound to a poly(I:C) RNA ligand

Toll-like Receptor 3 (TLR3) initiates a potent anti-viral immune response by binding to double-stranded RNA ligands. Previous crystallographic studies showed that TLR3 forms a homodimer when bound to a 46-base pair RNA ligand. However, this short RNA fails to initiate a robust immune response. To ob...

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Detalles Bibliográficos
Autores principales:	Lim, Chan Seok, Jang, Yoon Ha, Lee, Ga Young, Han, Gu Min, Jeong, Hye Jin, Kim, Ji Won, Lee, Jie-Oh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653405/ https://www.ncbi.nlm.nih.gov/pubmed/36371424 http://dx.doi.org/10.1038/s41467-022-34602-0

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