Multimeric ACE2-IgM fusions as broadly active antivirals that potently neutralize SARS-CoV-2 variants

Coronavirus infections are a world-wide threat to human health. A promising strategy to develop a broadly active antiviral is the use of fusion proteins consisting of an antibody IgG Fc region and a human ACE2 domain to which the viral spike proteins bind. Here we create antiviral fusion proteins ba...

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Detalles Bibliográficos
Autores principales: Svilenov, Hristo L., Bester, Romina, Sacherl, Julia, Absmeier, Ramona, Peters, Carsten, Protzer, Ulrike, Brockmeyer, Carsten, Buchner, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653429/
https://www.ncbi.nlm.nih.gov/pubmed/36371561
http://dx.doi.org/10.1038/s42003-022-04193-z

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