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Long-range GABAergic projections contribute to cortical feedback control of sensory processing
In the olfactory system, the olfactory cortex sends glutamatergic projections back to the first stage of olfactory processing, the olfactory bulb (OB). Such corticofugal excitatory circuits — a canonical circuit motif described in all sensory systems— dynamically adjust early sensory processing. Her...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653434/ https://www.ncbi.nlm.nih.gov/pubmed/36371430 http://dx.doi.org/10.1038/s41467-022-34513-0 |
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author | Mazo, Camille Nissant, Antoine Saha, Soham Peroni, Enzo Lledo, Pierre-Marie Lepousez, Gabriel |
author_facet | Mazo, Camille Nissant, Antoine Saha, Soham Peroni, Enzo Lledo, Pierre-Marie Lepousez, Gabriel |
author_sort | Mazo, Camille |
collection | PubMed |
description | In the olfactory system, the olfactory cortex sends glutamatergic projections back to the first stage of olfactory processing, the olfactory bulb (OB). Such corticofugal excitatory circuits — a canonical circuit motif described in all sensory systems— dynamically adjust early sensory processing. Here, we uncover a corticofugal inhibitory feedback to OB, originating from a subpopulation of GABAergic neurons in the anterior olfactory cortex and innervating both local and output OB neurons. In vivo imaging and network modeling showed that optogenetic activation of cortical GABAergic projections drives a net subtractive inhibition of both spontaneous and odor-evoked activity in local as well as output neurons. In output neurons, stimulation of cortical GABAergic feedback enhances separation of population odor responses in tufted cells, but not mitral cells. Targeted pharmacogenetic silencing of cortical GABAergic axon terminals impaired discrimination of similar odor mixtures. Thus, corticofugal GABAergic projections represent an additional circuit motif in cortical feedback control of sensory processing. |
format | Online Article Text |
id | pubmed-9653434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-96534342022-11-15 Long-range GABAergic projections contribute to cortical feedback control of sensory processing Mazo, Camille Nissant, Antoine Saha, Soham Peroni, Enzo Lledo, Pierre-Marie Lepousez, Gabriel Nat Commun Article In the olfactory system, the olfactory cortex sends glutamatergic projections back to the first stage of olfactory processing, the olfactory bulb (OB). Such corticofugal excitatory circuits — a canonical circuit motif described in all sensory systems— dynamically adjust early sensory processing. Here, we uncover a corticofugal inhibitory feedback to OB, originating from a subpopulation of GABAergic neurons in the anterior olfactory cortex and innervating both local and output OB neurons. In vivo imaging and network modeling showed that optogenetic activation of cortical GABAergic projections drives a net subtractive inhibition of both spontaneous and odor-evoked activity in local as well as output neurons. In output neurons, stimulation of cortical GABAergic feedback enhances separation of population odor responses in tufted cells, but not mitral cells. Targeted pharmacogenetic silencing of cortical GABAergic axon terminals impaired discrimination of similar odor mixtures. Thus, corticofugal GABAergic projections represent an additional circuit motif in cortical feedback control of sensory processing. Nature Publishing Group UK 2022-11-12 /pmc/articles/PMC9653434/ /pubmed/36371430 http://dx.doi.org/10.1038/s41467-022-34513-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Mazo, Camille Nissant, Antoine Saha, Soham Peroni, Enzo Lledo, Pierre-Marie Lepousez, Gabriel Long-range GABAergic projections contribute to cortical feedback control of sensory processing |
title | Long-range GABAergic projections contribute to cortical feedback control of sensory processing |
title_full | Long-range GABAergic projections contribute to cortical feedback control of sensory processing |
title_fullStr | Long-range GABAergic projections contribute to cortical feedback control of sensory processing |
title_full_unstemmed | Long-range GABAergic projections contribute to cortical feedback control of sensory processing |
title_short | Long-range GABAergic projections contribute to cortical feedback control of sensory processing |
title_sort | long-range gabaergic projections contribute to cortical feedback control of sensory processing |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653434/ https://www.ncbi.nlm.nih.gov/pubmed/36371430 http://dx.doi.org/10.1038/s41467-022-34513-0 |
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